Viral Subversion of the Nuclear Pore Complex

Viruses

Valerie Le Sage¹ 

[1] Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Quebec H3T 1E2, Canada

关键词: viruses;    nuclear pore complex;    nucleoporins;    nucleocytoplasmic transport;   

DOI  :  10.3390/v5082019

来源: mdpi

【 摘 要 】

The nuclear pore complex (NPC) acts as a selective barrier between the nucleus and the cytoplasm and is responsible for mediating communication by regulating the transport of RNA and proteins. Numerous viral pathogens have evolved different mechanisms to hijack the NPC in order to regulate trafficking of viral proteins, genomes and even capsids into and out of the nucleus thus promoting virus replication. The present review examines the different strategies and the specific nucleoporins utilized during viral infections as a means of promoting their life cycle and inhibiting host viral defenses.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.