Insights into the function of ESCRT and its role in enveloped virus infection

Frontiers in Microbiology

Microbiology

Chunxuan Wang¹  Yu Chen¹  Shunlin Hu¹  Xiufan Liu² 

[1] Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou, China;Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou University, Yangzhou, China;Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou University, Yangzhou, China;Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou, China;

关键词: ESCRT;    MVBS;    enveloped virus;    viral entry;    viral budding;    viral replication;   

DOI  :  10.3389/fmicb.2023.1261651

 received in 2023-07-19, accepted in 2023-09-20,  发布年份 2023

来源: Frontiers

【 摘 要 】

The endosomal sorting complex required for transport (ESCRT) is an essential molecular machinery in eukaryotic cells that facilitates the invagination of endosomal membranes, leading to the formation of multivesicular bodies (MVBs). It participates in various cellular processes, including lipid bilayer remodeling, cytoplasmic separation, autophagy, membrane fission and re-modeling, plasma membrane repair, as well as the invasion, budding, and release of certain enveloped viruses. The ESCRT complex consists of five complexes, ESCRT-0 to ESCRT-III and VPS4, along with several accessory proteins. ESCRT-0 to ESCRT-II form soluble complexes that shuttle between the cytoplasm and membranes, mainly responsible for recruiting and transporting membrane proteins and viral particles, as well as recruiting ESCRT-III for membrane neck scission. ESCRT-III, a soluble monomer, directly participates in vesicle scission and release, while VPS4 hydrolyzes ATP to provide energy for ESCRT-III complex disassembly, enabling recycling. Studies have confirmed the hijacking of ESCRT complexes by enveloped viruses to facilitate their entry, replication, and budding. Recent research has focused on the interaction between various components of the ESCRT complex and different viruses. In this review, we discuss how different viruses hijack specific ESCRT regulatory proteins to impact the viral life cycle, aiming to explore commonalities in the interaction between viruses and the ESCRT system.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Chen, Hu and Liu.