Histone lactylation regulates cancer progression by reshaping the tumor microenvironment

Frontiers in Immunology

Immunology

Zhiheng Sun¹  Junxing Qu²  Peizhi Li³ 

[1] College of Life Science, Institute of Biomedical Science, Henan Normal University, Xinxiang, Henan, China;Institutes of Health Central Plains, Xinxiang Medical University, Xinxiang, China;The First People’s Hospital of Xinxiang City, The Fifth Clinical College of Xinxiang Medical University, Xinxiang, China;

关键词: lactylation;    tumor microenvironment;    immune cells;    cancer therapy;    epigenetic modification;   

DOI  :  10.3389/fimmu.2023.1284344

 received in 2023-08-28, accepted in 2023-10-13,  发布年份 2023

来源: Frontiers

【 摘 要 】

As a major product of glycolysis and a vital signaling molecule, many studies have reported the key role of lactate in tumor progression and cell fate determination. Lactylation is a newly discovered post-translational modification induced by lactate. On the one hand, lactylation introduced a new era of lactate metabolism in the tumor microenvironment (TME), and on the other hand, it provided a key breakthrough point for elucidation of the interaction between tumor metabolic reprogramming and epigenetic modification. Studies have shown that the lactylation of tumor cells, tumor stem cells and tumor-infiltrating immune cells in TME can participate in the development of cancer through downstream transcriptional regulation, and is a potential and promising tumor treatment target. This review summarized the discovery and effects of lactylation, as well as recent research on histone lactylation regulating cancer progression through reshaping TME. We also focused on new strategies to enhance anti-tumor effects via targeting lactylation. Finally, we discussed the limitations of existing studies and proposed new perspectives for future research in order to further explore lactylation targets. It may provide a new way and direction to improve tumor prognosis.

【 授权许可】

Unknown   
Copyright © 2023 Qu, Li and Sun