Association of non-HDL-C and depression: a cross-sectional analysis of the NHANES data

Frontiers in Psychiatry

Psychiatry

Suhong Wang¹  Xianlin Zhu¹  Yanping Shu²  Yiwen Zhao³  Lu Li³  Qiankun Huang⁴  Jiaoying Liu⁵ 

[1] Department of Clinical Psychology, The Third Affiliated Hospital of Soochow University, Changzhou, China;Department of Psychiatry of Women and Children, The Second People's Hospital of Guizhou Province, Guivang, China;Department of Psychiatry, Linhai Kangning Hospital, Linhai, China;Department of Psychology, Yichang Mental Health Center, Yichang, China;Graduate School of Zunyi Medical University, Zunyi Medical University, Zunyi, China;Department of Psychiatry of Women and Children, The Second People's Hospital of Guizhou Province, Guivang, China;

关键词: non-HDL-C;    depression;    NHANES;    cholesterol;    survey;   

DOI  :  10.3389/fpsyt.2023.1274648

 received in 2023-08-08, accepted in 2023-09-26,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesNon-high-density lipoprotein cholesterol (non-HDL-C) has attracted attention because it is associated with a variety of diseases and is easy to measure. However, the relationship between non-HDL-C and depression is still unclear. Our aim was to assess the relationship between non-HDL-C and depression using the cross-sectional NHANES survey from 2005 to 2018.MethodsWe examined the association between non-HDL-C and depression using weighted multivariable logistic regression models and subgroup analysis. Sensitivity analysis demonstrated the robustness of the results.ResultsThere were 42,143 participants in this study and 8.6% had depression (weighted 7.53%). Non-HDL-C was higher in participants with depression compared to those without depression (weighted mean 3.64 vs. 3.73, p < 0.01). There was a positive association between non-HDL-C and depression with a 95% OR of 1.22 adjusted for multifactorial (95% CI,1.03–1.45). In subgroup analyses, non-HDL-C was positively associated with depression in men (OR, 1.31; 95% CI, 1.01–1.70), normal BMI (OR: 0.93; 95% CI: 0.66–1.32) and in participants without hypertension (OR, 1.29; 95% CI, 1.01–1.66).ConclusionNon-HDL-C positively correlated with depression, and further research may be better for clinical service.

【 授权许可】

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Copyright © 2023 Zhu, Zhao, Li, Liu, Huang, Wang and Shu.