Disturbed sleep is associated with reduced verbal episodic memory and entorhinal cortex volume in younger middle-aged women with risk-reducing early ovarian removal

Frontiers in Endocrinology

Endocrinology

Michelle Jacobson¹  Marcus Q. Bernardini¹  William Foulkes²  Alana Brown³  Rebekah Reuben³  Mateja Perovic³  Kazakao Laird³  Laura Gravelsins³  Gina Nicoll³  Laurice Karkaby³  Shreeyaa Ramana³  Rosanna K. Olsen⁴  Cheryl Grady⁴  Nicole J. Gervais⁵  Gillian Einstein⁶  M. Natasha Rajah⁷  Lea Velsher⁸ 

[1] Cancer Clinical Research Unit, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada;Department of Human Genetics, McGill University, Montreal, QC, Canada;Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, QC, Canada;Department of Psychology, University of Toronto, Toronto, ON, Canada;Department of Psychology, University of Toronto, Toronto, ON, Canada;Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada;Department of Psychology, University of Toronto, Toronto, ON, Canada;Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada;Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, Netherlands;Department of Psychology, University of Toronto, Toronto, ON, Canada;Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada;Tema Genus, Linköping University, Linköping, Sweden;Women’s College Research Institute, Toronto, ON, Canada;Departments of Psychiatry and Douglas Research Centre, McGill University, Montreal, QC, Canada;Department of Psychology, Toronto Metropolitan University, Toronto, ON, Canada;Genetics Program, North York General Hospital, Toronto, ON, Canada;

关键词: bilateral salpingo-oophorectomy;    BRCA1/2;    estradiol;    sleep phenotype;    verbal episodic memory;    structural neuroimaging;    entorhinal cortex;   

DOI  :  10.3389/fendo.2023.1265470

 received in 2023-07-22, accepted in 2023-09-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionWomen with early ovarian removal (<48 years) have an elevated risk for both late-life Alzheimer’s disease (AD) and insomnia, a modifiable risk factor. In early midlife, they also show reduced verbal episodic memory and hippocampal volume. Whether these reductions correlate with a sleep phenotype consistent with insomnia risk remains unexplored. MethodsWe recruited thirty-one younger middleaged women with risk-reducing early bilateral salpingo-oophorectomy (BSO), fifteen of whom were taking estradiol-based hormone replacement therapy (BSO+ERT) and sixteen who were not (BSO). Fourteen age-matched premenopausal (AMC) and seventeen spontaneously peri-postmenopausal (SM) women who were ~10y older and not taking ERT were also enrolled. Overnight polysomnography recordings were collected at participants’ home across multiple nights (M=2.38 SEM=0.19), along with subjective sleep quality and hot flash ratings. In addition to group comparisons on sleep measures, associations with verbal episodic memory and medial temporal lobe volume were assessed. ResultsIncreased sleep latency and decreased sleep efficiency were observed on polysomnography recordings of those not taking ERT, consistent with insomnia symptoms. This phenotype was also observed in the older women in SM, implicating ovarian hormone loss. Further, sleep latency was associated with more forgetting on the paragraph recall task, previously shown to be altered in women with early BSO. Both increased sleep latency and reduced sleep efficiency were associated with smaller anterolateral entorhinal cortex volume. DiscussionTogether, these findings confirm an association between ovarian hormone loss and insomnia symptoms, and importantly, identify an younger onset age in women with early ovarian removal, which may contribute to poorer cognitive and brain outcomes in these women.

【 授权许可】

Unknown   
Copyright © 2023 Gervais, Gravelsins, Brown, Reuben, Perovic, Karkaby, Nicoll, Laird, Ramana, Bernardini, Jacobson, Velsher, Foulkes, Rajah, Olsen, Grady and Einstein