Screening for ovarian cancer in women with varying levels of risk, using annual tests, results in high recall for repeat screening tests

Hereditary Cancer in Clinical Practice

Ros Eeles⁴  Sarah Thomas⁴  Audrey Ardern-Jones⁴  Susan Shanley⁴  Chris Haracopos⁴  Martin Gore²  Jane E Bridges²  John H Shepherd²  Thomas EJ Ind²  Desmond PJ Barton²  Ann Ward⁴  Ian Jacobs³  Paul Pharoah⁵  Fiona Lennard⁴  Eleanor Moskovic¹  Elizabeth Bancroft⁴  Marielle AE Nobbenhuis² 

[1] Department of Radiology, The Institute of Cancer Research & The Royal Marsden Foundation Trust, Cotswold Road and Fulham Road, SW3 6JJ, London, UK;Department of Gynaecological Oncology, The Institute of Cancer Research & The Royal Marsden Foundation Trust, Cotswold Road and Fulham Road, SW3 6JJ, London, UK;Department of Gynaecological Oncology, UCL, 1st Floor Maple House, 149 Tottenham Court Road, London W1T 7NF London UK;Section of Cancer Genetics, The Institute of Cancer Research & The Royal Marsden Foundation Trust, Cotswold Road and Fulham Road, SW3 6JJ, London, UK;Cancer Research UK Human Cancer Genetics Group, Department of Oncology, University of Cambridge, Hills Road, CB2 0QQ, Cambridge, UK

关键词: bilateral salpingo-oophorectomy;    BRCA gene mutation;    serum CA125;    transvaginal ultrasound;    screening;    ovarian cancer;   

Others  :  806558
DOI  :  10.1186/1897-4287-9-11

 received in 2011-08-30, accepted in 2011-11-23,  发布年份 2011

【 摘 要 】

Background

We assessed ovarian cancer screening outcomes in women with a positive family history of ovarian cancer divided into a low-, moderate- or high-risk group for development of ovarian cancer.

Methods

545 women with a positive family history of ovarian cancer referred to the Ovarian Screening Service at the Royal Marsden Hospital, London from January 2000- December 2008 were included. They were stratified into three risk-groups according to family history (high-, moderate- and low-risk) of developing ovarian cancer and offered annual serum CA 125 and transvaginal ultrasound screening. The high-risk group was offered genetic testing.

Results

The median age at entry was 44 years. The number of women in the high, moderate and low-risk groups was 397, 112, and 36, respectively. During 2266 women years of follow-up two ovarian cancer cases were found: one advanced stage at her fourth annual screening, and one early stage at prophylactic bilateral salpingo-oophorectomy (BSO). Prophylactic BSO was performed in 138 women (25.3%). Forty-three women had an abnormal CA125, resulting in 59 repeat tests. The re-call rate in the high, moderate and low-risk group was 14%, 3% and 6%. Equivocal transvaginal ultrasound results required 108 recalls in 71 women. The re-call rate in the high, moderate, and low-risk group was 25%, 6% and 17%.

Conclusion

No early stage ovarian cancer was picked up at annual screening and a significant number of re-calls for repeat screening tests was identified.

【 授权许可】

   
2011 Nobbenhuis et al; licensee BioMed Central Ltd.

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