Regional myocardial function after intracoronary bone marrow cell injection in reperfused anterior wall infarction - a cardiovascular magnetic resonance tagging study

Journal of Cardiovascular Magnetic Resonance

Research

Kolbjørn Forfang¹  Thor Edvardsen¹  Ketil Lunde¹  Svend Aakhus¹  Svein Solheim²  Harald Arnesen³  Einar Hopp⁴  Hans-Jørgen Smith⁴ 

[1] Department of Cardiology, Oslo University Hospital, Rikshospitalet, Norway;Department of Cardiology, Oslo University Hospital, Ullevål, Norway;Department of Cardiology, Oslo University Hospital, Ullevål, Norway;Faculty of Medicine, University of Oslo, Oslo, Norway;Department of Radiology, Oslo University Hospital, Postbox 4950, Rikshospitalet, 0424, Nydalen, Oslo, Norway;

关键词: Left Ventricular Ejection Fraction;    Cardiovascular Magnetic Resonance;    Left Anterior Descend;    Late Gadolinium Enhancement;    Intraclass Correlation Coefficient;   

DOI  :  10.1186/1532-429X-13-22

 received in 2010-11-17, accepted in 2011-03-17,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundTrials have brought diverse results of bone marrow stem cell treatment in necrotic myocardium. This substudy from the Autologous Stem Cell Transplantation in Acute Myocardial Infarction trial (ASTAMI) explored global and regional myocardial function after intracoronary injection of autologous mononuclear bone marrow cells (mBMC) in acute anterior wall myocardial infarction treated with percutaneous coronary intervention.MethodsCardiovascular magnetic resonance (CMR) tagging was performed 2-3 weeks and 6 months after revascularization in 15 patients treated with intracoronary stem cell injection (mBMC group) and in 13 controls without sham injection. Global and regional left ventricular (LV) strain and LV twist were correlated to cine CMR and late gadolinium enhancement (LGE).ResultsIn the control group myocardial function as measured by strain improved for the global LV (6 months: -13.1 ± 2.4 versus 2-3 weeks: -11.9 ± 3.4%, p = 0.014) and for the infarct zone (-11.8 ± 3.0 versus -9.3 ± 4.1%, p = 0.001), and significantly more than in the mBMC group (inter-group p = 0.027 for global strain, respectively p = 0.009 for infarct zone strain). LV infarct mass decreased (35.7 ± 20.4 versus 45.7 ± 29.5 g, p = 0.024), also significantly more pronounced than the mBMC group (inter-group p = 0.034). LV twist was initially low and remained unchanged irrespective of therapy.ConclusionsLGE and strain findings quite similarly demonstrate subtle differences between the mBMC and control groups. Intracoronary injection of autologous mBMC did not strengthen regional or global myocardial function in this substudy.Trial registrationClinicalTrials.gov: NCT00199823

【 授权许可】

CC BY   
© Hopp et al; licensee BioMed Central Ltd. 2011