Biomimetic approaches with smart interfaces for bone regeneration

Journal of Biomedical Science

Review

P. Ramesh¹  H. K. Varma¹  Sajith Vellappally²  G. S. Sailaja³  Sukumaran Anil⁴ 

[1] Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, 695 012, Thiruvananthapuram, India;Dental Biomaterials Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia;Department of Polymer Science and Rubber Technology, Cochin University of Science and Technology, 682 022, Cochin, India;Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University, Post Box 153, AIKharj 11942, Riyadh, Saudi Arabia;

关键词: Bone regeneration;    Biomimetic;    Cell-material interaction;    Orthopaedic;    Smart interface;    Bone tissue engineering;   

DOI  :  10.1186/s12929-016-0284-x

 received in 2016-01-16, accepted in 2016-09-05,  发布年份 2016

来源: Springer

【 摘 要 】

A ‘smart tissue interface’ is a host tissue-biomaterial interface capable of triggering favourable biochemical events inspired by stimuli responsive mechanisms. In other words, biomaterial surface is instrumental in dictating the interface functionality. This review aims to investigate the fundamental and favourable requirements of a ‘smart tissue interface’ that can positively influence the degree of healing and promote bone tissue regeneration. A biomaterial surface when interacts synergistically with the dynamic extracellular matrix, the healing process become accelerated through development of a smart interface. The interface functionality relies equally on bound functional groups and conjugated molecules belonging to the biomaterial and the biological milieu it interacts with. The essential conditions for such a special biomimetic environment are discussed. We highlight the impending prospects of smart interfaces and trying to relate the design approaches as well as critical factors that determine species-specific functionality with special reference to bone tissue regeneration.

【 授权许可】

CC BY   
© The Author(s). 2016