The clinical behavior of mixed ductal/lobular carcinoma of the breast: a clinicopathologic analysis

World Journal of Surgical Oncology

Research

Lakshmi P Paruchuri¹  Aparna Suryadevara¹  Nassim Banisaeed²  Gary Dunnington³  Krishna A Rao⁴ 

[1] Department of Internal Medicine, Southern Illinois University School of Medicine (SIU), Springfield, IL, USA;Department of Pathology, Memorial Medical Center, 701 North First Street, 62781, Springfield, IL, USA;Department of Surgery, Southern Illinois University School of Medicine (SIU), Springfield, IL, USA;Simmons Cancer Institute at Southern Illinois University, Post Office Box 19677, 62794-9677, Springfield, IL, USA;Division of Hematology-Oncology, Department of Internal Medicine, Southern Illinois University School of Medicine (SIU), Springfield, IL, USA;Simmons Cancer Institute at Southern Illinois University, Post Office Box 19677, 62794-9677, Springfield, IL, USA;

关键词: Ductal Carcinoma;    Invasive Ductal Carcinoma;    Lobular Carcinoma;    Invasive Lobular Carcinoma;    Contralateral Breast;   

DOI  :  10.1186/1477-7819-8-51

 received in 2010-01-25, accepted in 2010-06-21,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundTo date, the clinical presentation and prognosis of mixed ductal/lobular mammary carcinomas has not been well studied, and little is known about the outcome of this entity. Thus, best management practices remain undetermined due to a dearth of knowledge on this topic.MethodsIn this paper, we present a clinicopathologic analysis of patients at our institution with this entity and compare them to age-matched controls with purely invasive ductal carcinoma (IDC) and historical data from patients with purely lobular carcinoma and also stain-available tumor specimens for E-cadherin. We have obtained 100 cases of ductal and 50 cases of mixed ductal/lobular breast carcinoma.ResultsClinically, the behavior of mixed ductal/lobular tumors seemed to demonstrate some important differences from their ductal counterparts, particularly a lower rate of metastatic spread but with a much higher rate of second primary breast cancers.ConclusionsOur data suggests that mixed ductal/lobular carcinomas are a distinct clinicopathologic entity incorporating some features of both lobular and ductal carcinomas and representing a pleomorphic variant of IDC.

【 授权许可】

Unknown   
© Suryadevara et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.