The invasive lobular carcinoma as a prototype luminal A breast cancer: A retrospective cohort study

BMC Cancer

Research Article

Kyung Hwan Shin¹  Seung-Ho Shin¹  Eun-A Kim¹  Han-Sung Kang¹  Keun Seok Lee¹  In Hae Park¹  Seeyoun Lee¹  Youngmee Kwon¹  So-Youn Jung¹  Junsoo Jeong¹  Seok Won Kim¹  Jungsil Ro¹  Kyoung Lan Ko¹ 

[1] Center for Breast Cancer, National Cancer Center, Goyang-si, South Korea;

关键词: Overall Survival;    Estrogen Receptor;    Invasive Ductal Carcinoma;    Invasive Lobular Carcinoma;    Large Tumor Size;   

DOI  :  10.1186/1471-2407-10-664

 received in 2010-08-27, accepted in 2010-12-03,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundAlthough the invasive lobular carcinoma (ILC) is the second most frequent histologic subtype in Western countries, its incidence is much lower in Asia, and its characteristics are less well known.MethodsWe assessed the clinical characteristics and outcomes of 83 Korean patients (2.8%) with ILC for comparison with 2,833 (97.2%) with the invasive ductal carcinoma (IDC), including 1,088 (37.3%) with the luminal A subtype (LA-IDC).ResultsThe mean age of all patients was 48.2 years, with no significant differences among the groups. Compared to IDC, ILC showed a larger tumor size (≥T2, 59.8% vs. 38.8%, P = 0.001), a lower histologic grade (HG 1/2, 90.4% vs. 64.4%, P < 0.001), more frequent estrogen receptor positive (90.4% vs. 64.4%, P < 0.001), progesterone receptor positive (71.1% vs. 50.1%, P < 0.001) and HER2 negative (97.5% vs. 74.6%, P < 0.001) status, and lower Ki-67 expression (10.3% ± 10.6% vs. 20.6% ± 19.8%, P < 0.001), as well as being more likely to be of the luminal A subtype (91.4% vs. 51.2%, P < 0.001). Six (7.2%) ILC and 359 (12.7%) IDC patients developed disease recurrence, with a median follow-up of 56.4 (range 4.9-136.6) months. The outcome of ILC was close to LA-IDC (HR 0.77 for recurrence, 95% CI 0.31-1.90, P = 0.57; HR 0.75 for death, 95% CI 0.18-3.09, P = 0.70) and significantly better than for the non-LA-IDC (HR 1.69 for recurrence, 95% CI 1.23-2.33, P = 0.001; HR 1.50 for death, 95% CI 0.97-2.33, P = 0.07).ConclusionsILC, a rare histologic type of breast cancer in Korea, has distinctive clinicopathological characteristics similar to those of LA-IDC.

【 授权许可】

Unknown   
© Jung et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.