Dynamics and prognostic role of galectin-3 in patients with advanced heart failure, during left ventricular assist device support and following heart transplantation

BMC Cardiovascular Disorders

Research Article

Em-Claire Que-Xu¹  Donna Mancini¹  Ulrich P. Jorde¹  D’Vesharronne Moore¹  Christina Wu¹  Raymond Givens¹  Ruiping Ji¹  Tomoko S. Kato¹  Ellie Coromilas¹  P. Christian Schulze²  Hiroo Takayama³  Yoshifumi Naka³  Isaac George³ 

[1] Department of Medicine, Division of Cardiology, Columbia University Medical Center, 166 Fort Washington Avenue, 10032, New York, NY, USA;Department of Medicine, Division of Cardiology, Columbia University Medical Center, 166 Fort Washington Avenue, 10032, New York, NY, USA;Department of Medicine, Division of Cardiology, Angiology, Pneumology and Intensive Medical Care, Friedrich-Schiller-University Jena, Erlanger Allee 101, 07743, Jena, Germany;Division of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, 166 Fort Washington Avenue, 10032, New York, NY, USA;

关键词: Heart Failure;    Galectin-3;    LVAD;    Heart Transplantation;    Coronary Allograft Vasculopathy;   

DOI  :  10.1186/s12872-016-0298-z

 received in 2016-03-02, accepted in 2016-05-23,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundGalectin-3 is a marker of myocardial inflammation and fibrosis shown to correlate with morbidity and mortality in heart failure (HF). We examined the utility of galectin-3 as a marker of the severity of HF, the response of galectin-3 levels to ventricular assist device (LVAD) implantation or heart transplantation (HTx), and its use as a prognostic indicator.MethodsPlasma galectin-3 was measured using a commercially available ELISA assay in patients with stable HF (n = 55), severe HF (n = 63), at 3 (n = 17) and 6 (n = 14) months post-LVAD and at LVAD explantation (n = 23), patients following HTx (n = 85) and healthy controls (n = 30).ResultsGalectin-3 levels increase with the severity of HF (severe HF: 28.2 ± 14, stable HF: 19.7 ± 13, p = 0.001; controls: 13.2 ± 9 ng/ml, p = 0.02 versus stable HF). Following LVAD implantation, galectin-3 levels are initially lower (3 months: 23.7 ± 9, 6 months: 21.7 ± 9 versus 29.2 ± 14 ng/ml implantation; p = NS) but are higher at explantation (40.4 ± 19 ng/ml; p = 0.005 versus pre-LVAD). Galectin-3 levels >30 ng/ml are associated with lower survival post-LVAD placement (76.5 % versus 95.0 % at 2 years, p = 0.009). After HTx, galectin-3 levels are lower (17.8 ± 7.1 ng/ml post-HTx versus 28.2 ± 14 pre-HTx; p < 0.0001). Patients with coronary allograft vasculopathy (CAV) post-HTx showed higher galectin-3 levels (20.5 ± 8.8 ng/ml versus 16.8 ± 6.3, p = 0.1) and the degree of CAV correlated with levels of galectin-3 (r2 = 0.17, p < 0.0001).ConclusionsGalectin-3 is associated with the severity of HF, exhibits dynamic changes during mechanical unloading and predicts survival post-LVAD. Further, galectin-3 is associated with the development on CAV post-HTx. Galectin-3 might serve as a novel biomarker in patients with HF, during LVAD support and following HTx.

【 授权许可】

CC BY   
© The Author(s). 2016