Viral infections in outpatients with medically attended acute respiratory illness during the 2012–2013 influenza season

BMC Infectious Diseases

Research Article

Theresa M Sax¹  GK Balasubramani¹  Stephen Wisniewski¹  Heather F Eng¹  Richard K Zimmerman²  Jonathan M Raviotta²  Mary Patricia Nowalk²  Krissy K Moehling²  Charles R Rinaldo³  Arlene Bullotta⁴ 

[1] Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA;Department of Family Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;Departments of Infectious Disease and Microbiology, and Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA;Departments of Infectious Disease and Microbiology, and Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA;

关键词: Influenza;    Viral infections;    Virus detection;    RSV;   

DOI  :  10.1186/s12879-015-0806-2

 received in 2014-11-19, accepted in 2015-02-04,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundWhile it is known that acute respiratory illness (ARI) is caused by an array of viruses, less is known about co-detections and the resultant comparative symptoms and illness burden. This study examined the co-detections, the distribution of viruses, symptoms, and illness burden associated with ARI between December 2012 and March 2013.MethodsOutpatients with ARI were assayed for presence of 18 viruses using multiplex reverse transcriptase polymerase chain reaction (MRT-PCR) to simultaneously detect multiple viruses.ResultsAmong 935 patients, 60% tested positive for a single virus, 9% tested positive for ≥1 virus and 287 (31%) tested negative. Among children (<18 years), the respective distributions were 63%, 14%, and 23%; whereas for younger adults (18–49 years), the distributions were 58%, 8%, and 34% and for older adults (≥50 years) the distributions were 61%, 5%, and 32% (P < 0.001). Co-detections were more common in children than older adults (P = 0.01), and less frequent in households without children (P = 0.003). Most frequently co-detected viruses were coronavirus, respiratory syncytial virus, and influenza A virus. Compared with single viral infections, those with co-detections less frequently reported sore throat (P = 0.01), missed fewer days of school (1.1 vs. 2 days; P = 0.04), or work (2 vs. 3 days; P = 0.03); other measures of illness severity did not vary.ConclusionsAmong outpatients with ARI, 69% of visits were associated with a viral etiology. Co-detections of specific clusters of viruses were observed in 9% of ARI cases particularly in children, were less frequent in households without children, and were less symptomatic (e.g., lower fever) than single infections.

【 授权许可】

Unknown   
© Zimmerman et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.