Translation and validation of the EORTC brain cancer module (EORTC QLQ-BN20) for use in Iran

Health and Quality of Life Outcomes

Research

Azam Mardani¹  Mir Saeed Yekaninejad²  Alireza Khoshnevisan³  Shahab Kamali Ardakani³  Neil K Aaronson⁴  Amir H Pakpour⁵ 

[1]Brain and Spinal Injury Research Center (BASIR), Imam Khomeini Hospital Complex, Tehran University of medical sciences, Tehran, Iran

[2]Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

[3]Brain and Spinal Injury Research Center (BASIR), Imam Khomeini Hospital Complex, Tehran University of medical sciences, Tehran, Iran

[4]Department of neurosurgery, Shariati hospital, Tehran University of medical sciences, Tehran, Iran

[5]Division of Psychosocial Research & Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, the Netherlands

[6]Qazvin Research Center for Social Determinants of Health, Qazvin University of Medical Sciences, Qazvin, Iran

[7]Department of Public Health, Qazvin University of Medical Sciences, Qazvin, Iran

关键词: Quality of life;    Brain cancer, QLQ-BN20;    QLQ-C30;    Psychometric evaluation;   

DOI  :  10.1186/1477-7525-10-54

 received in 2012-02-21, accepted in 2012-05-20,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe aim of this study was to translate the EORTC quality of life questionnaire for brain cancer, the QLQ-BN20, into Persian, and to evaluate its psychometric properties when used among brain cancer patients in Iran.MethodsA standard backward and forward translation procedure was used to generate the Persian language version of the QLQ-BN20. The QLQ-BN20 was administered together with the QLQ-C30 to 194 patients diagnosed with primary brain cancer. Multitrait scaling and confirmatory factor analysis (CFA) were used to evaluate the hypothesized scale structure of the questionnaire. Internal consistency reliability was estimated with Cronbach’s alpha. The ability of the QLQ-BN20 to distinguish between patient subgroups formed on the basis of performance status and cognitive status was evaluated, as was the responsiveness of the questionnaire to changes in performance status over time.ResultsMultitrait scaling and CFA results confirmed the hypothesized scale structure. The measurement model was consistent across men and women. Internal consistency reliability of the multi-item scales ranged from 0.74 to 0.89. The QLQ-BN20 distinguished clearly between patients with relatively good versus poor performance and cognitive status, and changes in scores over time reflected changes observed in performance status ratings.ConclusionsThese results support the validity and reliability of the QLQ-BN20 for use among Iranian patients diagnosed with primary brain cancer. Future studies should examine the psychometrics of the questionnaire when used in patients with brain metastasis.

【 授权许可】

Unknown   
© Khoshnevisan et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.