Increase of aqueous inflammatory factors in macular edema with branch retinal vein occlusion: a case control study

Journal of Inflammation

Research

Katsunori Shimada¹  Tatsuya Mimura²  Hidetaka Noma³  Hideharu Funatsu³ 

[1] Department of Hygiene and Public Health II, Tokyo Women's Medical University, Tokyo, Japan;Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan;Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Chiba, Japan;

关键词: Vascular Endothelial Growth Factor;    Macular Edema;    Aqueous Humor;    Vascular Endothelial Growth Factor Level;    Macular Hole;   

DOI  :  10.1186/1476-9255-7-44

 received in 2010-05-26, accepted in 2010-08-26,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThis study investigated whether soluble intercellular adhesion molecule-1 (sICAM-1) has a role in the pathogenesis of macular edema associated with branch retinal vein occlusion (BRVO) together with vascular endothelial growth factor (VEGF).MethodsA retrospective case control study was performed in 22 patients with BRVO and macular edema, as well as 10 patients with nonischemic ocular diseases as the control group. Retinal ischemia was evaluated by measuring the area of capillary non-perfusion with Scion Image software, while the severity of macular edema was examined by optical coherence tomography. Aqueous humor samples were obtained during the performance of combined vitrectomy and cataract surgery. sICAM-1 and VEGF levels in aqueous humor and plasma specimens were determined by enzyme-linked immunosorbent assay.ResultsAqueous humor levels of sICAM-1 (median: 6.90 ng/ml) and VEGF (median: 169 pg/ml) were significantly elevated in BRVO patients compared with the control group (median: 3.30 pg/ml and 15.6 pg/ml, respectively) (P = 0.005 and P < 0.001, respectively). The aqueous humor level of sICAM-1 was significantly correlated with that of VEGF (P = 0.025). In addition, aqueous levels of both sICAM-1 and VEGF were correlated with the size of the non-perfused area of the retina in BRVO patients (P = 0.021 and P < 0.001, respectively). Furthermore, aqueous levels of sICAM-1 and VEGF were both correlated with the severity of macular edema (P = 0.020 and P = 0.005, respectively).ConclusionsBoth sICAM-1 and VEGF may be involved in the pathogenesis of macular edema associated with BRVO. Measurement of aqueous humor sICAM-1 levels may be useful for assessment of BRVO patients with macular edema, in addition to measurement of VEGF.

【 授权许可】

CC BY   
© Noma et al; licensee BioMed Central Ltd. 2010