Visual acuity and foveal thickness after vitrectomy for macular edema associated with branch retinal vein occlusion: a case series

BMC Ophthalmology

Research Article

Katsunori Shimada¹  Shuichiro Eguchi²  Tatsuya Mimura³  Hidetaka Noma⁴  Hideharu Funatsu⁴ 

[1] Department of Hygiene and Public Health II, Tokyo Women's Medical University, Tokyo, Japan;Department of Ophthalmology, Eguchi Eye Hospital, Hakodate, Japan;Department of Ophthalmology, University of Tokyo Graduate School of Medicine, Tokyo, Japan;Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Chiba, Japan;

关键词: Vascular Endothelial Growth Factor;    Visual Acuity;    Macular Edema;    Retinal Pigment Epithelial Cell;    Vascular Endothelial Growth Factor Level;   

DOI  :  10.1186/1471-2415-10-11

 received in 2009-12-09, accepted in 2010-04-29,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe mechanism by which vitrectomy improves macular edema in patients with branch retinal vein occlusion remains unclear, although intraocular levels of vascular endothelial growth factor have been suggested to influence the visual prognosis and macular edema.MethodsA series of 54 consecutive patients (54 eyes) with branch retinal vein occlusion was studied prospectively. All patients underwent pars plana vitrectomy for treatment of macular edema. Best corrected visual acuity and retinal thickness (examined by optical coherence tomography) were assessed before and after surgery. The level of vascular endothelial growth factor in vitreous fluid harvested at operation was determined. Patients were followed for at least 6 months postoperatively.ResultsBoth the visual acuity and the retinal thickness showed significant improvement at 6 months postoperatively (P = 0.0002 and P < 0.0001, respectively). The vitreous level of vascular endothelial growth factor was significantly higher in patients who showed less improvement of visual acuity compared with those who had a better visual prognosis (p = 0.0135). In contrast, a high vitreous level of vascular endothelial growth factor was associated with greater improvement of macular edema (p = 0.0064).ConclusionsThese results suggest that the vitreous level of vascular endothelial growth factor might influence the visual prognosis and the response of macular edema to vitrectomy in patients with branch retinal vein occlusion.

【 授权许可】

CC BY   
© Noma et al; licensee BioMed Central Ltd. 2010