Differential effect of corn oil-based low trans structured fat on the plasma and hepatic lipid profile in an atherogenic mouse model: comparison to hydrogenated trans fat

Lipids in Health and Disease

Short Report

Eun-Young Kwon¹  Seon-Min Jeon¹  Yun-Young Cho¹  Myung-Sook Choi¹  Ki-Teak Lee²  Hye-Jin Kim³ 

[1] Department of Food Science and Nutrition, Kyungpook National University, Daegu, South Korea;Food and Nutritional Genomics Research Center, Kyungpook National University, Daegu, South Korea;Department of Food Science and Technology, Chungnam National University, Daejeon;Food R&D, CJ Cheiljedang Corp., Seoul, South Korea;

关键词: Trans Fatty Acid;    Coronary Heart Disease Risk;    Hepatic Lipid;    Carnitine Palmitoyl Transferase;    Fecal Lipid;   

DOI  :  10.1186/1476-511X-10-15

 received in 2010-12-23, accepted in 2011-01-20,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundTrans fat are not desirable in many aspects on health maintenance. Low trans structured fats have been reported to be relatively more safe than trans fats.MethodsWe examined the effects of low trans structured fat from corn oil (LC), compared with high trans fat shortening, on cholesterol and fatty acid metabolism in apo E deficient mice which is an atherogenic animal model. The animals were fed a high trans fat (10% fat: commercial shortening (CS)) or a low trans fat (LC) diet for 12 weeks.ResultsLC decreased apo B and hepatic cholesterol and triglyceride concentration compared to the CS group but significantly increased plasma total cholesterol and triglyceride concentration and fecal lipids with a simultaneous increase in HDL-cholesterol level, apo A-I, and the ratio of HDL-cholesterol to total cholesterol (HTR). Reduction of hepatic lipid levels by inclusion of LC intake was observed alongside modulation of hepatic enzyme activities related to cholesterol esterification, fatty acid metabolism and fecal lipids level compared to the CS group. The differential effects of LC intake on the plasma and hepatic lipid profile seemed to be partly due to the fatty acid composition of LC which contains higher MUFA, PUFA and SFA content as well as lower content of trans fatty acids compared to CS.ConclusionsWe suggest that LC may exert a dual effect on plasma and hepatic lipid metabolism in an atherogenic animal model. Accordingly, LC, supplemented at 10% in diet, had an anti-atherogenic effect on these apo E-/-mice, and increased fecal lipids, decreased hepatic steatosis, but elevated plasma lipids. Further studies are needed to verify the exact mode of action regarding the complex physiological changes and alteration in lipid metabolism caused by LC.

【 授权许可】

Unknown   
© Cho et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.