Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes

Cardiovascular Diabetology

Original Investigation

Vinod Patel¹  Ranjit Mohan Anjana²  Kuppan Gokulakrishnan²  Viswanathan Mohan²  Rajendra Pradeepa²  Ramamurthy Jayashri²  Gyanendra Tripathi³  Hema Venkataraman³  Nithya Sukumar³  Antonysunil Adaikalakoteswari³  Philip G McTernan³  Ponnusamy Saravanan⁴  Sudhesh Kumar⁵ 

[1] Academic department of Diabetes and Metabolism, George Eliot Hospital, Nuneaton, UK;Department of Epidemiology & Diabetology, Madras Diabetes Research Foundation & Dr.Mohan’s Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control & IDF Centre of Education, 4, Conran Smith Road, Gopalapuram, 600 086, Chennai, India;Warwick Medical School, University of Warwick, Coventry, UK;Warwick Medical School, University of Warwick, Coventry, UK;Academic department of Diabetes and Metabolism, George Eliot Hospital, Nuneaton, UK;WISDEM centre, University Hospital Coventry and Warwickshire, Coventry, UK;Warwick Medical School, University of Warwick, Coventry, UK;WISDEM centre, University Hospital Coventry and Warwickshire, Coventry, UK;

关键词: Coronary Artery Disease;    Diabetes Patient;    Metformin;    Homocysteine;    Carnitine Palmitoyl Transferase;   

DOI  :  10.1186/s12933-014-0129-4

 received in 2014-07-03, accepted in 2014-08-20,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundMetformin, a standard therapy in type 2 diabetes, reduces vitamin B12 levels. Studies linking low vitamin B12 levels and cardiovascular disease are equivocal and suggest improving B12 levels may help in primary prevention. The role of vitamin B12 deficiency on cardiovascular risk factors, especially in type 2 diabetes has not been explored. The aim of this study is to investigate whether vitamin B12 deficiency in type 2 diabetes patients is associated with cardiovascular risk factors in two different ethnic groups in UK and India.MethodsType 2 diabetes patients from two secondary care diabetic centres (Europeans - UK and Indians - India) were studied. Serum vitamin B12, folate and biochemical parameters were measured.ResultsThe prevalence rates of vitamin B12 deficiency (<191 ng/L) were 27% and 12% in Europeans and Indians, respectively and higher in metformin treated type 2 diabetes patients. In linear regression analysis, after adjusting for all likely confounding factors, vitamin B12 independently associated with triglycerides in both the populations and cholesterol/HDL ratio in Indians. Logistic regression showed type 2 diabetes patients with vitamin B12 deficiency were at significantly higher odds of having coexisting coronary artery disease (CAD) in Europeans with similar but non-significant trend in Indians, after adjusting for all likely confounding factors.ConclusionsThe prevalence of vitamin B12 deficiency is common in type 2 diabetes patients and is associated with adverse lipid parameters. Type 2 diabetes management guidelines should include the recommendation for regular testing for B12 levels, especially for those on metformin.

【 授权许可】

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© Adaikalakoteswari et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.