Severe hypovitaminosis D correlates with increased inflammatory markers in HIV infected patients

BMC Infectious Diseases

Research Article

Stephanie Ewing¹  Laurence Duvillard¹  Jean-Claude Guilland¹  Delphine Croisier²  Sophie Mahy²  Thiphaine Ansemant³  Pascal Chavanet⁴  Lionel Piroth⁴  Christine Piroth⁵  Paul Ornetti⁶  Jean-Francis Maillefert⁷ 

[1] INSERM U866 and Laboratory of biochemistry, CHU, Dijon, France;Infectious Diseases Department, CHU, 21079, Dijon, France;Infectious Diseases Department, CHU, 21079, Dijon, France;Rheumatology Department, CHU, F-21078, Dijon, France;Infectious Diseases Department, CHU, 21079, Dijon, France;University of Burgundy, F-21079, Dijon, France;Rheumatology Department, CHU, F-21078, Dijon, France;Rheumatology Department, CHU, F-21078, Dijon, France;INSERM U887, F-21079, Dijon, France;Rheumatology Department, CHU, F-21078, Dijon, France;University of Burgundy, F-21079, Dijon, France;INSERM U887, F-21079, Dijon, France;

关键词: Antiretroviral therapy;    Bone metabolism;    HIV;    Inflammation;    25-hydroxyvitamin D;   

DOI  :  10.1186/1471-2334-13-7

 received in 2012-05-18, accepted in 2012-12-14,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundEven though it has been suggested that antiretroviral therapy has an impact on severe hypovitaminosis D (SHD) in HIV infected patients, it could be speculated that the different levels of residual inflammation on HAART (Highly Active Anti Retroviral Therapy) could contribute to SHD and aggravate bone catabolism in these patients.MethodsA cross-sectional study was carried out in an unselected cohort of 263 HIV infected outpatients consulting during Spring 2010. Clinical examinations were performed and medical history, food habits, sun exposure and addictions were collected. Fasting blood samples were taken for immunological, virological, inflammation, endocrine and bone markers evaluations.ResultsNinety-five (36%) patients had SHD. In univariate analysis, a significant and positive association was found between SHD and IL6 (p = 0.001), hsCRP (p = 0.04), increased serum C-Telopeptides X (CTX) (p = 0.005) and Parathyroid Hormon (PTH) (p < 0.0001) levels. In multivariate analysis, SHD deficiency correlated significantly with increased IL-6, high serum CTX levels, lower mean daily exposure to the sun, current or past smoking, hepatitis C, and functional status (falls), but not with the time spent on the current HAART (by specific drug or overall).ConclusionsSHD is frequent and correlates with inflammation in HIV infected patients. Since SHD is also associated with falls and increased bone catabolism, it may be of interest to take into account not only the type of antiretroviral therapy but also the residual inflammation on HAART in order to assess functional and bone risks. This finding also suggests that vitamin D supplementation may be beneficial in these HIV-infected patients.

【 授权许可】

Unknown   
© Ansemant et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.