The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis

BMC Medical Genetics

Research Article

Victor Moreno¹  M. Henar Alonso¹  Virginia Lope²  Nuria Aragonés²  Marina Pollán²  Beatriz Perez-Gomez³  José María Huerta⁴  Rosana Peiró Pérez⁵  Vicente Martín⁶  Gemma Castaño-Vinyals⁷  Manolis Kogevinas⁸  José Juan Jiménez Moleon⁹  Pilar Amiano^1,10  Adonina Tardón^1,11  Carmen González-Donquiles^1,12  Rocío Capelo^1,13  Jéssica Alonso-Molero^1,14  Antonio J. Molina^1,14  Tania Fernández-Villa^1,14  Elena Ramos^1,14  Marcela Guevara^1,15  Camilo Palazuelos^1,16  Inés Gómez Acebo^1,17  Javier Llorca^1,17 

[1] CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Cancer Prevention and Control Program, Catalan Institute of Oncology, Hospitalet de Llobregat, Barcelona, Spain;Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain;Colorectal Cancer Group, Bellvitge Biomedical Research Institute (IDIBELL). Hospitalet de Llobregat, Barcelona, Spain;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Cancer and Environmental Epidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Cancer and Environmental Epidemiology Unit, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain;Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta De Hierro, Madrid, Spain;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Dirección General de Salud Pública, Fundación para el fomento de la investigación sanitaria y biomédica de la Comunidad Valenciana, FISABIO-Salud Pública, Barcelona, Spain;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Grupo de Investigación en Interacciones Gen-Ambiente y Salud de la Universidad de León, León, Spain;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain;IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain;Universitat Pompeu Fabra (UPF), Barcelona, Spain;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain;IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain;Universitat Pompeu Fabra (UPF), Barcelona, Spain;School of Public Health, Athens, Greece;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Instituto de Salud Pública de Navarra, Pamplona, Navarra, Spain;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;Oncology Institute IUOPA, Universidad de Oviedo, Oviedo, Asturias, Spain;Centro de Investigación Biomédica en Red (CIBERESP) and Oviedo University; Departamento de Ciencias Biomédicas. Universidad de León. Campus de Vegazana, León, Spain;Centro de Investigación en Salud y Medio Ambiente (CYSMA), Universidad de Huelva, Huelva, Spain;Grupo de Investigación en Interacciones Gen-Ambiente y Salud. Instituto de Biomedicina (IBIOMED), Universidad de León, León, Spain;Instituto de Salud Pública de Navarra, Pamplona, Navarra, Spain;Universidad de Cantabria, Santander, Spain;Universidad de Cantabria, Santander, Spain;CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain;

关键词: Colorectal cancer;    SMAD7;    rs4939827;    Mediterranean diet;    Gene-environment;   

DOI  :  10.1186/s12881-017-0485-5

 received in 2016-11-07, accepted in 2017-10-18,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe objective of our investigation is to study the relationship between the rs4939827 SNP in the SMAD7 gene, Mediterranean diet pattern and the risk of colorectal cancer.MethodsWe examined 1087 cases of colorectal cancer and 2409 population controls with available DNA samples from the MCC-Spain study, 2008–2012. Descriptive statistical analyses, and multivariate logistic mixed models were performed. The potential synergistic effect of rs4939827 and the Mediterranean diet pattern was evaluated with logistic regression in different strata of of adherence to the Mediterranean diet and the genotype.ResultsHigh adherence to Mediterrenean diet was statistically significantly associated with colorectal cancer risk. A decreased risk for CRC cancer was observed for the CC compared to the TT genotype (OR = 0.65 and 95% CI = 0.51–0.81) of the rs4939827 SNP Also, we could show an association between the Mediterranean diet pattern (protective factor) and rs4939827. Although the decreased risk for the CC genotype was slightly more pronounced in subjects with high adherence to Mediterrenean diet, there was no statistically significant synergistic effect between genotype CC and adherence to the Mediterranean dietary pattern factors.ConclusionThe SMAD7 gene and specifically the allele C could be protective for colorectal cancer. An independent protective association was also observed between high adherence Mediterranean diet pattern and CRC risk. Findings form this study indicate that high adherence to Mediterranean diet pattern has a protective role for CRC cancer probably involving the Tumor Growth Factor- β pathway in this cancer.

【 授权许可】

CC BY   
© The Author(s). 2017