Evaluating the effect of poly (amidoamine) treated bioactive glass nanoparticle incorporated in universal adhesive on bonding to artificially induced caries affected dentin

BMC Oral Health

Research

Rajalakshmanan Eswaramoorthy¹  Vijay Venkatesh Kondas²  Akhil C. Rao³  Pradeep Kumar Yadalam⁴  Vidyashree Nandini⁵  Ravi Kirana⁶ 

[1] Department of Biomaterials, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India;Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University (ASTU), PO. 18888, Adama, Ethiopia;Department of Conservative Dentistry and Endodontics, SRM Kattankulathur Dental College and Hospital, SRM Institute Of Science And Technology, SRM Nagar, Kattankulathur, Kanchipuram, 603203, Chennai, Tamilnadu, India;Department of Conservative Dentistry and Endodontics, School Of Dental Sciences Krishna Institute, Malkapur, 415110, Karad, Maharashtra, India;Department of Periodontics, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College, Saveetha University, 600077, Chennai, India;Department of Prosthodontics and Implantology, SRM Kattankulathur Dental College and Hospital, SRM Institute Of Science And Technology, SRM Nagar, Kattankulathur, Kanchipuram, 603203, Chennai, Tamilnadu, India;High Temperature Material Processing Laboratory, Department of Physics and Nanotechnology, SRM Institute of Science and Technology, Kattankulathur, 603203, Chengalpattu, Tamil Nadu, India;

关键词: PAMAM dendrimer;    Caries-affected dentin;    PAMAM-loaded bioactive glass nanoparticles;    Universal adhesive;    Remineralizing demineralized dentin;   

DOI  :  10.1186/s12903-023-03536-4

 received in 2023-02-07, accepted in 2023-10-12,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThe purpose of this study was to evaluate remineralisation and its effect on microtensile bond-strength of artificially induced caries affected dentin (CAD) when treated with a commercial universal adhesive modified with poly(amidoamine) dendrimer (PAMAM) loaded mesoporous bioactive glass nanoparticles (A-PMBG).Material and methodsMesoporous bioactive glass nanoparticles (MBG) were synthesised using sol–gel process, where PAMAM was loaded (P-MBG) and added to commercial adhesive at different weight percentages (0.2, 0.5, 1 and 2 wt%). First, rheological properties of commercial and modified adhesives were evaluated. The effect of remineralization/hardness and microtensile bond-strength (MTBs) of those samples that mimicked the rheological properties of commercial adhesives were evaluated using Vickers hardness tester and universal testing machine respectively. Scanning-Electron microscope was used to visualize failed samples of MTBs and remineralization samples. Both evaluations were carried out at 1-,3 and 6-month intervals, samples being stored in stimulated salivary fluid during each time interval.ResultsAddition of nanoparticles altered the rheological properties. With increase in the weight percentage of nanoparticles in commercial adhesive, there was significant increase in degree of conversion, viscosity and sedimentation rate (p < 0.05). The 0.2 and 0.5 wgt% groups closely mimicked the properties of commercial adhesive and were evaluated for remineralization and MTBs. After 6 months, 0.2wgt% group showed increased MTBs (p < 0.05) and 0.5wgt% group increased remineralization/hardness (p < 0.05).ConclusionThe complex of PAMAM-MBG-Universal adhesive can remineralize the demineralised CAD thereby improving its bond-strength when evaluated for up to 6-months.

【 授权许可】

CC BY   
© The Author(s) 2023

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