Current challenges in understanding immune cell functions during septic syndromes

BMC Immunology

Review

Zechariah Franks¹  McKenzie Carlisle¹  Matthew T Rondina² 

[1] Program in Molecular Medicine, 84112,, Salt Lake City, Utah, USA;Program in Molecular Medicine, 84112,, Salt Lake City, Utah, USA;Division of General Internal Medicine, University of Utah School of Medicine, 84112,, Salt Lake City, Utah, USA;

关键词: Sepsis;    Neutrophils;    Dendritic cells;    Infection;    Inflammation;    Immunity;   

DOI  :  10.1186/s12865-015-0073-4

 received in 2014-10-07, accepted in 2015-02-05,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundSepsis is a dynamic infectious disease syndrome characterized by dysregulated inflammatory responses.ResultsDespite decades of research, improvements in the treatment of sepsis have been modest.These limited advances are likely due, in part, to multiple factors, including substantial heterogeneity in septic syndromes, significant knowledge gaps in our understanding of how immune cells function in sepsis, and limitations in animal models that accurately recapitulate the human septic milieu.The goal of this brief review is to describe current challenges in understanding immune cell functions during sepsis. We also provide a framework to guide scientists and clinicians in research and patient care as they strive to better understand dysregulated cell responses during sepsis. ConclusionsAdditional, well-designed translational studies in sepsis are critical for enhancing our understanding of the role of immune cells in sepsis.

【 授权许可】

Unknown   
© Franks et al.; licensee BioMed Central. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.