The gut microbiome in human immunodeficiency virus infection

BMC Medicine

Minireview

Gili Zilberman-Schapira¹  Niv Zmora¹  Stavros Bashiardes¹  Shlomik Itav¹  Eran Elinav¹  Hila Elinav² 

[1] Department of Immunology, Weizmann Institute of Science, 234 Herzl Street, 76100, Rehovot, Israel;Hadassah AIDS Center, Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University Medical Center, 91120, Jerusalem, Israel;

关键词: Microbiota;    Dysbiosis;    Gastrointestinal tract;    AIDS;    HIV;    Anti-retroviral therapy;    CD4+ T cells;   

DOI  :  10.1186/s12916-016-0625-3

 received in 2015-12-04, accepted in 2016-05-10,  发布年份 2016

来源: Springer

【 摘 要 】

HIV/AIDS causes severe dysfunction of the immune system through CD4+ T cell depletion, leading to dysregulation of both the adaptive and innate immune arms. A primary target for viral infection is the gastrointestinal tract, which is a reservoir of CD4+ T cells. In addition to being a major immune hub, the human gastrointestinal tract harbors trillions of commensal microorganisms, the microbiota, which have recently been shown to play critical roles in health. Alterations in the composition and function of microbiota have been implicated in a variety of ‘multi-factorial’ disorders, including infectious, autoimmune, metabolic, and neoplastic disorders. It is widely accepted that, in addition to its direct role in altering the gastrointestinal CD4+ T cell compartment, HIV infection is characterized by gut microbiota compositional and functional changes. Herein, we review such alterations and discuss their potential local and systemic effects on the HIV-positive host, as well as potential roles of novel microbiota-targeting treatments in modulating HIV progression and associated adverse systemic manifestations.

【 授权许可】

CC BY   
© Zilberman-Schapira et al. 2016