Association between different insulin resistance surrogates and infertility in reproductive-aged females

BMC Public Health

Research

Weiting Xia¹  Yaoyao Cai²  Sisi Zhang³  Shenghao Wu⁴ 

[1] Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China;Department of Obstetrics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China;Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China;Reproductive Medicine Center, Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Yuying Children’s Hospital of Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China;

关键词: Female infertility;    Insulin resistance;    Insulin resistance surrogates;    Triglyceride glucose-body mass index;    NHANES;   

DOI  :  10.1186/s12889-023-16813-2

 received in 2023-03-22, accepted in 2023-09-21,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundObesity and metabolic syndrome are observed more frequently in infertile women, and insulin resistance (IR) is closely related to them. However, there are no studies that have examined the association between different IR surrogates and female infertility, hence we investigated the potential association between them in the general population.MethodsThis was a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES, 2013–2018). The association of different IR surrogates (HOMA-IR index, TyG index and TyG-BMI index) with female infertility was estimated by multivariable regression analysis.ResultsAfter adjusting for confounders, the HOMA-IR index and TyG index did not show an association with female infertility, while the TyG-BMI index was found to have a positive association with female infertility (OR = 1.01, 95% CI: 1.00, 1.01; P < 0.0001), and the OR of the TyG-BMI group T3 (≥ 255.55) was significantly different compared to the group T1 (< 185.31) (OR = 3.02, 95% CI: 1.62, 5.60). Similar results were seen in most of the subgroup participants by stratified analysis (P-interaction > 0.05). However, different IR surrogates did not show variability in their ability to predict infertility [TyG-BMI: 0.68 (95% CI: 0.62, 0.74) vs. TyG: 0.62 (95% CI: 0.57, 0.68) vs. HOMA-IR: 0.65 (95% CI: 0.60, 0.71)].ConclusionsOur result suggests that high levels of TyG-BMI index were positively associated with female infertility in US reproductive-aged females.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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