Triglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes

Lipids in Health and Disease

Chunyuan Jiang¹  Meng Yu¹  Mingchun Zhong¹  Ruijuan Yang²  Yang Zou³  Maobin Kuang³ 

[1] Department of Cardiology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, 330006, Nanchang, China;Department of Endocrinology, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, 330006, Nanchang, China;From the Jiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital Affiliated to Nanchang University, 330006, Nanchang, China;

关键词: Pre-diabetes;    TyG-BMI;    World Health Organization;    Triglyceride glucose-body mass index;    American Diabetes Association;   

DOI  :  10.1186/s12944-021-01594-7

来源: Springer

【 摘 要 】

BackgroundTriglyceride glucose-body mass index (TyG-BMI) has been recommended as an alternative indicator of insulin resistance. However, the association between TyG-BMI and pre-diabetes remains to be elucidated.MethodsMore than 100,000 subjects with normal glucose at baseline received follow-up. The main outcome event of concern was pre-diabetes defined according to the diagnostic criteria recommended by the American Diabetes Association (ADA) in 2018 and the World Health Organization (WHO) in 1999. A Cox proportional hazard regression model was used to evaluate the role of TyG-BMI in identifying people at high risk of pre-diabetes.ResultsAt a mean observation period of 3.1 years, the incidence of pre-diabetes in the cohort was 3.70 and 12.31% according to the WHO and ADA diagnostic criteria for pre-diabetes, respectively. The multivariate Cox regression analysis demonstrated that TyG-BMI was independently positively correlated with pre-diabetes, and there was a special population dependence phenomenon. Among them, non-obese people, women and people under 50 years old had a significantly higher risk of TyG-BMI-related pre-diabetes (P-interaction< 0.05).ConclusionsThese findings suggest that a higher TyG-BMI significantly increases an individual’s risk of pre-diabetes, and this risk is significantly higher in women, non-obese individuals, and individuals younger than 50 years of age.

【 授权许可】

CC BY