Quantifying the mosquito’s sweet tooth: modelling the effectiveness of attractive toxic sugar baits (ATSB) for malaria vector control

Malaria Journal

Research

John C Beier¹  Michael T White²  Azra C Ghani²  John M Marshall²  Gunter C Muller³  Yosef Schlein³ 

[1] Department of Epidemiology and Public Health, Miller School of Medicine, University of Miami, Miami, Florida, USA;Department of Infectious Disease Epidemiology, MRC Centre for Outbreak Analysis and Modelling, Imperial College London, London, UK;Department of Parasitology, Kuvin Center for the Study of Tropical and Infectious Diseases, Hadassah Medical School, Hebrew University, Jerusalem, Israel;

关键词: Malaria;    Indoor Residual Spray;    Coverage Level;    Entomological Inoculation Rate;    Female Mosquito;   

DOI  :  10.1186/1475-2875-12-291

 received in 2013-05-27, accepted in 2013-08-18,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundCurrent vector control strategies focus largely on indoor measures, such as long-lasting insecticide treated nets (LLINs) and indoor residual spraying (IRS); however mosquitoes frequently feed on sugar sources outdoors, inviting the possibility of novel control strategies. Attractive toxic sugar baits (ATSB), either sprayed on vegetation or provided in outdoor bait stations, have been shown to significantly reduce mosquito densities in these settings.MethodsSimple models of mosquito sugar-feeding behaviour were fitted to data from an ATSB field trial in Mali and used to estimate sugar-feeding rates and the potential of ATSB to control mosquito populations. The model and fitted parameters were then incorporated into a larger integrated vector management (IVM) model to assess the potential contribution of ATSB to future IVM programmes.ResultsIn the Mali experimental setting, the model suggests that about half of female mosquitoes fed on ATSB solution per day, dying within several hours of ingesting the toxin. Using a model incorporating the number of gonotrophic cycles completed by female mosquitoes, a higher sugar-feeding rate was estimated for younger mosquitoes than for older mosquitoes. Extending this model to incorporate other vector control interventions suggests that an IVM programme based on both ATSB and LLINs may substantially reduce mosquito density and survival rates in this setting, thereby substantially reducing parasite transmission. This is predicted to exceed the impact of LLINs in combination with IRS provided ATSB feeding rates are 50% or more of Mali experimental levels. In addition, ATSB is predicted to be particularly effective against Anopheles arabiensis, which is relatively exophilic and therefore less affected by IRS and LLINs.ConclusionsThese results suggest that high coverage with a combination of LLINs and ATSB could result in substantial reductions in malaria transmission in this setting. Further field studies of ATSB in other settings are needed to assess the potential of ATSB as a component in future IVM malaria control strategies.

【 授权许可】

CC BY   
© Marshall et al.; licensee BioMed Central Ltd. 2013