Apparent temperature and acute myocardial infarction hospital admissions in Copenhagen, Denmark: a case-crossover study

Environmental Health

Research

Thomas Ellermann¹  Matthias Ketzel¹  Steffen Loft²  Janine Wichmann³ 

[1] Department of Environmental Science, Aarhus University, Roskilde, Denmark;Section of Environmental Health, Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark;Section of Environmental Health, Department of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark;Section of Environmental Health, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5A, 1014, Copenhagen K, Denmark;

关键词: Temperature;    Acute myocardial infarction;    Hospital admissions;    Case-crossover design;   

DOI  :  10.1186/1476-069X-11-19

 received in 2012-03-02, accepted in 2012-03-30,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe influence of temperature on acute myocardial infarction (AMI) has not been investigated as extensively as the effects of broader outcomes of morbidity and mortality. Sixteen studies reported inconsistent results and two considered confounding by air pollution. We addressed some of the methodological limitations of the previous studies in this study.MethodsThis is the first study of the association between the daily 3-hour maximum apparent temperature (Tappmax) and AMI hospital admissions in Copenhagen. The study period covered 1 January 1999-31 December 2006, stratified in warm (April - September) and cold (October - March) periods. A case-crossover epidemiology study design was applied. Models were adjusted for public holidays and influenza, confounding by PM10, NO2 and CO was investigated, the lag and non-linear effects of Tappmax was examined, effect modification by age, sex and SES was explored, and the results of the case-crossover models were compared to those of the generalised additive Poisson time-series and generalised estimating equation models.Results14 456 AMI hospital admissions (12 995 people) occurred during the study period. For an inter-quartile range (6 or 7°C) increase in the 5-day cumulative average of Tappmax, a 4% (95% CI:-2%; 10%) and 9% (95% CI: 3%; 14%) decrease in the AMI admission rate was observed in the warm and cold periods, respectively. The 19-65 year old group, men and highest SES group seemed to be more susceptible in the cold period.ConclusionAn increase in Tappmax is associated with a decrease in AMI admissions during the colder months.

【 授权许可】

CC BY   
© Wichmann et al; licensee BioMed Central Ltd. 2012