Metastasis: new perspectives on an old problem

Molecular Cancer

Review

Sime Spaventi¹  Sandra Kraljevic Pavelic²  Kresimir Pavelic²  Hrvojka Bosnjak³  Mirela Sedic⁴ 

[1] Croatian Academy of Sciences and Arts, Zrinski trg 11, 10000, Zagreb, Croatia;Department of Biotechnology, University of Rijeka, 51000, Rijeka, Croatia;Department of Internal Medicine, University Hospital "Sisters Of Mercy", 10 000, Zagreb, Croatia;Division of Molecular Medicine, Rudjer Boskovic Institute, 10000, Zagreb, Croatia;

关键词: Cancer Stem Cell;    Normal Stem Cell;    Laryngeal Squamous Cell Carcinoma;    Brain Tumor Stem Cell;    Lung Squamous Carcinoma;   

DOI  :  10.1186/1476-4598-10-22

 received in 2010-09-14, accepted in 2011-02-22,  发布年份 2011

来源: Springer

【 摘 要 】

Many hypotheses have been postulated to explain the intricate nature of the metastatic process, but none of them completely accounted for the actual biological and clinical observations. Consequently, metastasis still remains an open issue with only few metastasis-inducing proteins experimentally validated so far. Recently proposed novel metastatic model, where serial and parallel metastatic processes are adequately integrated, might help to bridge the current gap between experimental results and clinical observations. In addition, the identification, isolation and molecular characterization of cancer stem cells, a population of the cells within the tumour mass able to proliferate, self-renew and induce tumorigenesis, will shed new light on the complex molecular events mediating metastasis, invasion and resistance to therapy. Understanding the molecular basis of these tumour characteristics will usher in a new age of individualized cancer therapy. In this review article, we will provide a current overview of molecular mechanisms underpinning metastasis, and discuss recent findings in this field obtained by global molecular profiling strategies such as proteomics.

【 授权许可】

CC BY   
© Kraljevic Pavelic et al; licensee BioMed Central Ltd. 2011