Cancer stem cell subsets and their relationships

Journal of Translational Medicine

Review

Xiao-Hua Zhang¹  Yi-Fei Pan¹  Hai-Guang Liu¹  Han Yang¹  Chong Chen¹ 

[1] Department of Oncology, The First Affiliated Hospital of Wenzhou Medical College, 325000, Wenzhou, China;

关键词: Stem Cell;    Cancer Stem Cell;    Invasive Ductal Carcinoma;    Inflammatory Breast Cancer;    Normal Stem Cell;   

DOI  :  10.1186/1479-5876-9-50

 received in 2010-12-13, accepted in 2011-05-04,  发布年份 2011

来源: Springer

【 摘 要 】

Emerging evidence suggests that cancer stem cells account for the initiation and progression of cancer. While many types of cancer stem cells with specific markers have been isolated and identified, a variety of differences among them began to be appreciated. Cancer stem cells are hierarchical populations that consist of precancerous stem cells, primary cancer stem cells, migrating cancer stem cells and chemoradioresistant cancer stem cells, playing different roles in cancer initiation and progression. Here we propose a new concept "horizontal hierarchy of cancer stem cells" to distinguish them from vertical hierarchy cancer stem cells, cancer transient-amplifying cells and cancer differentiated cells, and summarize our current understanding of these subsets of cancer stem cells with the aim to open up novel therapeutic strategies for cancer based on this understanding.

【 授权许可】

Unknown   
© Liu et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.