Genetic characterization of hantaviruses isolated from rodents in the port cities of Heilongjiang, China, in 2014

BMC Veterinary Research

Research Article

Suya Cao¹  Yulong Wang¹  Wendong Ju²  Cheng Cheng²  Jian Ma³ 

[1] Department of Wildlife Medicine, Wildlife Resources Faculty, Northeast Forestry University, 150040, Harbin, China;Heilongjiang International Travel Healthcare Center, 150001, Harbin, China;State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agriculture Sciences, 150001, Harbin, China;

关键词: Hantavirus;    SEOV;    HTNV;    Epidemiology;    Heilongjiang;   

DOI  :  10.1186/s12917-016-0695-7

 received in 2015-10-23, accepted in 2016-03-23,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundHantavirus is a tripartite negative-sense RNA virus. It can infect humans through contaminated rodent excreta and causes two types of fatal human diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). China exhibits the highest HFRS occurrence rate in the world, and the Heilongjiang area is one of the most severely infected regions.ResultsTo obtain additional insights into the genetic characteristics of hantaviruses in the port cities of the Heilongjiang area in China, a molecular epidemiological investigation of hantaviruses isolated from rodents was performed in 2014. A total of 649 rodents (11 murine species and 1 shrew species) were caught in 12 port cities in Heilongjiang. Among these rodents, the most common species was A. agrarius, and the second-most common was R. norvegicus. A viral gene PCR assay revealed the presence of two specific genotypes of hantavirus, referred to as Hantaan virus (HTNV) and Seoul virus (SEOV), and the positive SEOV infection rate was higher than that for HTNV. A genetic analysis based on partial M segment sequences indicated that all of the isolates belonging to SEOV could be assigned to two genetic lineages, whereas the isolate belonging to HTNV could be assigned to only one genetic lineage.ConclusionsThese results suggested that HTNV and SEOV are circulating in A. agrarius and R. norvegicus in the port cities in the area of Heilongjiang, but SEOV may be the dominant common hantavirus.

【 授权许可】

CC BY   
© Cao et al. 2016