Comparison of effects of diet versus exercise weight loss regimens on LDL and HDL particle size in obese adults

Lipids in Health and Disease

Short Report

Monica C Klempel¹  Surabhi Bhutani¹  Krista A Varady¹  Cynthia M Kroeger¹ 

[1] Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA;

关键词: Calorie restriction;    alternate day fasting;    endurance exercise;    weight loss;    LDL particle size;    HDL particle size;    cholesterol;    obese adults;   

DOI  :  10.1186/1476-511X-10-119

 received in 2011-06-02, accepted in 2011-07-18,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundObesity is associated with an atherogenic lipid profile characterized by a predominance of small LDL and HDL particles. Weight loss, by dietary restriction or exercise, increases LDL particle size. Whether these interventions can augment HDL size in conjunction with LDL size remains unknown.ObjectiveThis study compared the effects of alternate day fasting (ADF), calorie restriction (CR), and endurance exercise on LDL and HDL particle size in overweight and obese subjects.MethodsIn a 12-week parallel-arm trial, adult subjects (n = 60) were randomized to 1 of 4 groups: 1) ADF (75% energy restriction for 24-h alternated with ad libitum feeding for 24-h), 2) CR (25% energy restriction every day), 3) exercise (moderate intensity training 3 x/week), or 4) control.ResultsBody weight was reduced (P < 0.001) by ADF, CR, and exercise (5.2 ± 1.1%, 5.0 ± 1.4%, 5.1 ± 0.9%, respectively). Plasma LDL cholesterol decreased (P < 0.05) with ADF (10 ± 4%) and CR (8 ± 4%), whereas HDL cholesterol increased (P < 0.05) with exercise (16 ± 5%). Integrated LDL particle size was augmented (P = 0.01) by ADF and CR. The proportion of small LDL particles decreased (P = 0.04) with ADF only, and the proportion of large HDL particles increased (P = 0.03) with exercise only.ConclusionThese results indicate that dietary restriction increases LDL particle size, while endurance training augments HDL particle size, with minimal weight loss. None of these interventions concomitantly increased both LDL and HDL particle size, however.

【 授权许可】

CC BY   
© Varady et al; licensee BioMed Central Ltd. 2011