Comparison of effects of diet versus exercise weight loss regimens on LDL and HDL particle size in obese adults

Lipids in Health and Disease

Cynthia M Kroeger¹  Monica C Klempel¹  Surabhi Bhutani¹  Krista A Varady¹ 

[1] Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL, USA

关键词: obese adults;    cholesterol;    HDL particle size;    LDL particle size;    weight loss;    endurance exercise;    alternate day fasting;    Calorie restriction;   

Others  :  1212586
DOI  :  10.1186/1476-511X-10-119

 received in 2011-06-02, accepted in 2011-07-18,  发布年份 2011

【 摘 要 】

Background

Obesity is associated with an atherogenic lipid profile characterized by a predominance of small LDL and HDL particles. Weight loss, by dietary restriction or exercise, increases LDL particle size. Whether these interventions can augment HDL size in conjunction with LDL size remains unknown.

Objective

This study compared the effects of alternate day fasting (ADF), calorie restriction (CR), and endurance exercise on LDL and HDL particle size in overweight and obese subjects.

Methods

In a 12-week parallel-arm trial, adult subjects (n = 60) were randomized to 1 of 4 groups: 1) ADF (75% energy restriction for 24-h alternated with ad libitum feeding for 24-h), 2) CR (25% energy restriction every day), 3) exercise (moderate intensity training 3 x/week), or 4) control.

Results

Body weight was reduced (P < 0.001) by ADF, CR, and exercise (5.2 ± 1.1%, 5.0 ± 1.4%, 5.1 ± 0.9%, respectively). Plasma LDL cholesterol decreased (P < 0.05) with ADF (10 ± 4%) and CR (8 ± 4%), whereas HDL cholesterol increased (P < 0.05) with exercise (16 ± 5%). Integrated LDL particle size was augmented (P = 0.01) by ADF and CR. The proportion of small LDL particles decreased (P = 0.04) with ADF only, and the proportion of large HDL particles increased (P = 0.03) with exercise only.

Conclusion

These results indicate that dietary restriction increases LDL particle size, while endurance training augments HDL particle size, with minimal weight loss. None of these interventions concomitantly increased both LDL and HDL particle size, however.

【 授权许可】

   
2011 Varady et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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