Cryptococcus gattii molecular type VGII infection associated with lung disease in a goat

BMC Veterinary Research

Case Report

Camila Cecilia Martin¹  Fernando José Benesi¹  Priscilla Anne Melville²  Raquel Gonçalves Gomes³  Bruno Cogliati³  Alessandra Maria Dias Lacerda³  Evelin Catarine da Silva³  Lílian Rose Marques de Sá³  Danilo Marin Rodrigues³  Luciana Neves Torres³  Juliana Mariotti Guerra⁴  Rodrigo Albergaria Réssio⁵ 

[1] Clínica de Bovinos e Pequenos Ruminantes – Hospital Veterinário (HOVET), Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP), Av. Prof. Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-900, São Paulo, SP, Brazil;Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP), Av. Prof. Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270, São Paulo, SP, Brazil;Departamento de Patologia, Serviço de Patologia Animal – Hospital Veterinário (HOVET), Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP), Av. Prof. Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270, São Paulo, SP, Brazil;Departamento de Patologia, Serviço de Patologia Animal – Hospital Veterinário (HOVET), Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP), Av. Prof. Dr. Orlando Marques de Paiva 87, Cidade Universitária, 05508-270, São Paulo, SP, Brazil;Instituto Adolfo Lutz (IAL) - Centro de Patologia, Av. Dr. Arnaldo, 351 – 7o. Andar – Sala 705 - Pacaembú, 01246-000, São Paulo, SP, Brazil;Instituto Adolfo Lutz (IAL) - Centro de Patologia, Av. Dr. Arnaldo, 351 – 7o. Andar – Sala 705 - Pacaembú, 01246-000, São Paulo, SP, Brazil;

关键词: Cryptococcosis;    Pneumonia;    Goat;    Yeast;    Public health;   

DOI  :  10.1186/s12917-017-0950-6

 received in 2016-05-05, accepted in 2017-01-13,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundCryptococcus gattii-induced cryptococcosis is an emerging infectious disease of humans and animals with worldwide distribution and public health importance due to its significant morbidity and mortality rate. The present study aimed to report a case of pulmonary infection by C. gattii molecular type VGII in State of São Paulo, Brazil.Case presentationA 5-year-old goat showing intermittent dry cough, ruminal tympany, anorexia, fever, tachycardia and tachypnea was presented for necropsy at the Veterinary Hospital of the School of Veterinary Medicine and Animal Sciences, São Paulo University, São Paulo, Brazil. Postmortem examination revealed numerous 2.0–6.0 cm diameter yellow gelatinous pulmonary masses. Tissues were evaluated by a combination of pathological, mycological, and molecular diagnostic techniques. Microscopically, pneumonia granulomatous, multifocal to coalescing, moderate, with many intralesional carminophilic yeasts was observed. The immunohistochemistry and mycological culture confirmed Cryptococcus spp. Internal transcribed spacers and orotidine monophosphate pyrophosphorylase nucleotide differentiation demonstrated that the isolate corresponds to the C. gattii VGII molecular subtype.ConclusionsTo our knowledge, this is the first report of a pulmonary infection in a goat linked to C. gattii molecular type VGII in Southeastern Brazil. Our findings emphasize the need for an active surveillance program for human and animal new infections to improve the current public health policies due to expansion of the epidemiological niche of this important microorganism.

【 授权许可】

CC BY   
© The Author(s). 2017