Phosphatases in the cellular response to DNA damage

Cell Communication and Signaling

Review

Alvaro NA Monteiro¹  Alyson K Freeman² 

[1] Risk Assessment, Detection, and Intervention Program, H. Lee Moffitt Cancer Center and Research Institute, 33612, Tampa, Florida, USA;Risk Assessment, Detection, and Intervention Program, H. Lee Moffitt Cancer Center and Research Institute, 33612, Tampa, Florida, USA;University of South Florida Cancer Biology PhD Program, 33612, Tampa, Florida, USA;NCI-Frederick, P.O.Box B, Building 560, Mailstop 17, 21702, Frederick, MD, USA;

关键词: Pph3;    Ionize Radiation;    Okadaic Acid;    Replication Stress;    Methylmethane Sulfonate;   

DOI  :  10.1186/1478-811X-8-27

 received in 2010-07-13, accepted in 2010-09-22,  发布年份 2010

来源: Springer

【 摘 要 】

In the last fifteen years, rapid progress has been made in delineating the cellular response to DNA damage. The DNA damage response network is composed of a large number of proteins with different functions that detect and signal the presence of DNA damage in order to coordinate DNA repair with a variety of cellular processes, notably cell cycle progression. This signal, which radiates from the chromatin template, is driven primarily by phosphorylation events, mainly on serine and threonine residues. While we have accumulated detailed information about kinases and their substrates our understanding of the role of phosphatases in the DNA damage response is still preliminary. Identifying the phosphatases and their regulation will be instrumental to obtain a complete picture of the dynamics of the DNA damage response. Here we give an overview of the DNA damage response in mammalian cells and then review the data on the role of different phosphatases and discuss their biological relevance.

【 授权许可】

CC BY   
© Freeman and Monteiro; licensee BioMed Central Ltd. 2010