期刊论文详细信息
World Journal of Surgical Oncology | |
Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte colony-stimulating factor: a case report and literature review | |
Case Report | |
Taiki Sakamoto1  Seiji Nakamura1  Masakazu Iida1  Shintaro Kawano1  Teppei Jinno1  Yasuyuki Maruse1  Yuma Hashiguchi1  Ryota Matsubara1  Naoki Kaneko1  Yuichi Goto2  | |
[1]Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, 812-8582, Higashi-ku, Fukuoka, Japan | |
[2]Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, 812-8582, Higashi-ku, Fukuoka, Japan | |
[3]Maxillofacial Diagnostic and Surgical Science, Department of Oral and Maxillofacial Rehabilitation, Course for Developmental Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, 890-8544, Kagoshima, Japan | |
关键词: Squamous cell carcinoma; Parathyroid hormone-related protein; Granulocyte colony-stimulating factor; | |
DOI : 10.1186/s12957-016-0918-1 | |
received in 2015-11-24, accepted in 2016-06-15, 发布年份 2016 | |
来源: Springer | |
【 摘 要 】
BackgroundParaneoplastic syndrome generally results from tumor-derived hormones or peptides that cause metabolic derangements. Common metabolic conditions include hyponatremia, hypercalcemia, hypoglycemia, and Cushing’s syndrome. Herein, we report a very rare case of tongue carcinoma presenting with leukocytosis and hypercalcemia.Case presentationA 57-year-old man was admitted to our hospital with tongue squamous cell carcinoma (cT4aN0M0, stage IV). He underwent radical resection following preoperative chemoradiotherapy, but locoregional recurrence was detected 2 months after surgery. He presented with marked leukocytosis and hypercalcemia with elevated serum levels of granulocyte colony-stimulating factor (G-CSF) and parathyroid hormone-related protein (PTHrP). He was therefore managed with intravenous fluids, furosemide, prednisolone, elcatonin, and pamidronate. However, the patient died 1 month later of carcinomatous pleuritis following distant metastasis to the lung. Immunohistochemical analyses of the resected specimens revealed positive staining for PTHrP and G-CSF in the cancer cells.ConclusionsIn this case, it was considered that tumor-derived G-CSF and PTHrP caused leukocytosis and hypercalcemia.【 授权许可】
CC BY
© The Author(s). 2016
【 预 览 】
Files | Size | Format | View |
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RO202311109113153ZK.pdf | 1305KB | download |
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