Lymph-node ratio is an independent prognostic factor in patients with stage III colorectal cancer: a retrospective study from the Middle East

World Journal of Surgical Oncology

Research

Hasan Hattoum¹  Mohamad Eloubeidi²  Ali Shamseddine³  Deborah Mukherji³  Elias Elias³  Ahmad Saleh³  Walid Faraj⁴  Mohammad Khalife⁴  Ghassan K Abou-Alfa⁵  Hani Dimassi⁶ 

[1] Department of Internal Medicine, Staten Island University Hospital, 475 Seaview Ave, 10305, Staten Island, NY, USA;Division of Gastroenterology, Department of Internal Medicine, American University of Beirut, 1107 2020, Riad El-Solh, Beirut, Lebanon;Division of Hematology and Oncology, Department of Internal Medicine, American University of Beirut, 1107 2020, Riad El-Solh, Beirut, Lebanon;Division of Hepatobiliary and Gastric surgery, Department of General Surgery, American University of Beirut, 1107 2020, Riad El-Solh, Beirut, Lebanon;Memorial Sloan-Kettering Cancer Center, Section of Gastrointestinal Oncology, New York, NY, USA;School of Pharmacy, Lebanese American University, Byblos, Lebanon;

关键词: Colorectal cancer;    Stage III;    Lymph node ratio;    Prognosis;   

DOI  :  10.1186/1477-7819-10-63

 received in 2011-12-09, accepted in 2012-04-25,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundIn this retrospective study, we evaluated the prognostic effect of positive lymph-node ratio (pLNR) on patients with stage III colorectal cancer (CRC). Our paper is the first analysis, to our knowledge, to deal with such data from the Middle East.MethodsWe analyzed the clinicopathological data of 535 patients diagnosed with colorectal cancer at our institution between 1983 and 2003. The 164 patients diagnosed with stage III disease were divided into two categories based on lymph-node ratio (LNR) being the ratio of positive lymph nodes over total lymph nodes dissected: LNR ≤0.4 and LNR >0.4. We used Kaplan-Meier and Cox proportional hazard models to evaluate the prognostic effect of pLNR.ResultsThe 10-year survival rate for the patients with stage IIIA, IIIB and IIIC cancers were 76%, 56% and 0% respectively (P = 0.014). Using pLNR of 0.4 as the cutoff point was found to yield clinically and significant results, with a significant difference in the outcomes of patients with pLNR ≤0.4 compared to those with pLNR >0.4 (hazard ratio = 5.25, 95% confidence interval = 1.2 to 22.1, P = 0.02).ConclusionThe ratio-based staging (pLNR) of CRC is a more accurate and clinically useful prognostic method than the number of positive LNs resected or the total number of LNs retrieved for predicting the course of patients with stage III CRC.

【 授权许可】

Unknown   
© Elias et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.