Function and mechanism of tumor suppressor gene LRRC4/NGL-2

Molecular Cancer

Review

Guiyuan Li¹  Minghua Wu¹  Peiyao Li¹  Gang Xu² 

[1] Hunan Cancer Hospital and the Affiliated Tumor Hospital of Xiangya Medical School Central South University, Changsha, Hunan, China;Cancer Research Institute, Central South University, 410078, Changsha, Hunan, P.R. China;Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China;Key Laboratory of Carcinogenesis, Ministry of Health, Changsha, Hunan, China;Hunan Cancer Hospital and the Affiliated Tumor Hospital of Xiangya Medical School Central South University, Changsha, Hunan, China;Cancer Research Institute, Central South University, 410078, Changsha, Hunan, P.R. China;Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China;Key Laboratory of Carcinogenesis, Ministry of Health, Changsha, Hunan, China;Medical College, University of South China, Hengyang, Hunan, China;

关键词: Leucine-rich repeat;    Netrin, Netrin-G ligand;    miRNA;    Methylation;    Glioma;   

DOI  :  10.1186/1476-4598-13-266

 received in 2014-07-24, accepted in 2014-12-15,  发布年份 2014

来源: Springer

【 摘 要 】

LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2), a relatively specific expressed gene in brain tissue, is a member of the LRRC4/ NGL (netrin-G ligand) family and belongs to the superfamily of LRR proteins. LRRC4/NGL-2 regulates neurite outgrowth and lamina-specific dendritic segmentation, suggesting that LRRC4/NGL-2 is important for the development of the nervous system. In addition, LRRC4/NGL-2 has been identified as a tumor suppressor gene. The overexpression of LRRC4/NGL-2 suppresses glioma cell growth, angiogenesis and invasion through complicated signaling regulation networks. LRRC4/NGL-2 also has the ability to form multiphase loops with miRNA, transcription factors and gene methylation modification; the loss of LRRC4/NGL-2 function may be an important event in multiple biological processes in gliomas. In summary, LRRC4/NGL-2 is a critical gene in the normal development and tumorigenesis of the nervous system.

【 授权许可】

Unknown   
© Li et al.; licensee BioMed Central. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.