Prognostic value of poorly differentiated clusters in invasive breast cancer

World Journal of Surgical Oncology

Research

Hongyan Wang¹  Yili Wang¹  Jianjun He¹  Kai Wang¹  Ying Sun²  Fenli Liang³  Wei Cao⁴ 

[1] Center for Cancer Research, Department of Pathology, The First Affiliated Hospital of Xi’an Jiaotong University, 710061, Xi’an, China;Center for Cancer Research, Department of Pathology, The First Affiliated Hospital of Xi’an Jiaotong University, 710061, Xi’an, China;Department of Pathology, School of Medicine, Xi’an Jiaotong University, Xi’an, China;Center for Cancer Research, Department of Pathology, The First Affiliated Hospital of Xi’an Jiaotong University, 710061, Xi’an, China;Department of Pathology, Xi’an Medical College, Xi’an, China;Department of Oncology, Shaanxi Provincial People’s Hospital, Xi’an, China;

关键词: Breast cancer;    Poorly differentiated cluster;    Prognosis;   

DOI  :  10.1186/1477-7819-12-310

 received in 2014-04-14, accepted in 2014-10-01,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundOur study aimed to assess the prognostic value of poorly differentiated clusters (PDCs) in invasive breast cancer.MethodsA total of 146 cases of operable invasive ductal carcinoma that was not otherwise specified (IDC-NOS), from 2002 to 2009, were pathologically reviewed. Cancer clusters with five or more cancer cells and lacking gland-like structures were counted from a field containing maximum clusters in H & E slides under a × 20 objective lens (0.950 mm2 field of vision).ResultsTumors with <5, 5 to 9, and ≥10 clusters were graded as G1, G2, and G3, respectively (n =41, 60, and 45 tumors, respectively). An interobserver test showed good reproducibility, with a Cohen’s kappa coefficient of 0.739. The PDC grade was significantly associated with N stage (P <0.001), lymphovascular invasion (P =0.007), tumor budding grade (P <0.001), relapse rate (P <0.001), and death rate (P <0.001). Survival analyses revealed that the PDC grade was a significant prognostic factor for disease-free survival (hazard ratio 3.811; P <0.001) and overall survival (hazard ratio 3.730; P =0.001), independent of T stage, N stage, or tumor budding grade.ConclusionsThe PDC grade is an independent prognostic factor of IDC-NOS. Considering the simplicity and availability of this method relative to conventional clinical pathology, PDCs may serve as a novel prognostic histological characteristic in IDC-NOS.

【 授权许可】

Unknown   
© Sun et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.