Spectrum of gluten-related disorders: consensus on new nomenclature and classification

BMC Medicine

Opinion

Danilo Villalta¹  Peter HR Green²  Umberto Volta³  Katri Kaukinen⁴  David S Sanders⁵  Reiner Ullrich⁶  Michael Schumann⁶  Julio C Bai⁷  Marios Hadjivassiliou⁸  Kamran Rostami⁹  Carolina Ciacci^1,10  Alessio Fasano^1,11  Anna Sapone^1,12  Carlo Catassi^1,13  Jernej Dolinsek^1,14 

[1] Allergy and Clinical Immunology Unit, DML, AO Santa Maria degli Angeli, Pordenone, Italy;Celiac Disease Center, Columbia University, 10032, New York, NY, USA;Department of Digestive Diseases and Internal Medicine, St Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy;Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and School of Medicine, University of Tampere, Finland;Department of Gastroenterology and Hepatology, Royal Hallamshire Hospital and University of Sheffield Medical School, Sheffield, UK;Department of Gastroenterology, Rheumatology and Infectivology, Charité University Medicine, Berlin, Germany;Department of Medicine, Dr Carlos Bonorino Udaondo Gastroenterology Hospital, Buenos Aires, Argentina;Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK;Dudley Group of Hospitals, University of Birmingham Medical School, Birmingham, UK;Gastroenterology Unit, University of Salerno School of Medicine, Salerno, Italy;Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, 21201, Baltimore, MD, USA;Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, 21201, Baltimore, MD, USA;Department of Internal and Experimental Medicine Magrassi-Lanzara, Second University of Naples, Naples, Italy;Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, 21201, Baltimore, MD, USA;Department of Pediatrics, Università Politecnica delle Marche, Ancona, Italy;University Medical Centre Maribor, Ljubljansk, Slovenia;

关键词: Autism Spectrum Disorder;    Irritable Bowel Syndrome;    Celiac Disease;    Human Leukocyte Antigen;    Food Allergy;   

DOI  :  10.1186/1741-7015-10-13

 received in 2011-10-09, accepted in 2012-02-07,  发布年份 2012

来源: Springer

【 摘 要 】

A decade ago celiac disease was considered extremely rare outside Europe and, therefore, was almost completely ignored by health care professionals. In only 10 years, key milestones have moved celiac disease from obscurity into the popular spotlight worldwide. Now we are observing another interesting phenomenon that is generating great confusion among health care professionals. The number of individuals embracing a gluten-free diet (GFD) appears much higher than the projected number of celiac disease patients, fueling a global market of gluten-free products approaching $2.5 billion (US) in global sales in 2010. This trend is supported by the notion that, along with celiac disease, other conditions related to the ingestion of gluten have emerged as health care concerns. This review will summarize our current knowledge about the three main forms of gluten reactions: allergic (wheat allergy), autoimmune (celiac disease, dermatitis herpetiformis and gluten ataxia) and possibly immune-mediated (gluten sensitivity), and also outline pathogenic, clinical and epidemiological differences and propose new nomenclature and classifications.

【 授权许可】

Unknown   
© Sapone et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.