Contrasting effects of historical contingency on phenotypic and genomic trajectories during a two-step evolution experiment with bacteria

BMC Evolutionary Biology

Research Article

Claudine Médigue¹  Stéphane Cruveiller¹  Jessica Plucain²  Dominique Schneider²  Antonia Suau³  Mickaël Le Gac⁴ 

[1] Direction des Sciences du Vivant, CEA, Institut de Génomique, Genoscope & CNRS-UMR8030, Évry, France;Laboratoire d’Analyses Bioinformatiques en Génomique et Métabolisme, Évry, France;Univ. Grenoble Alpes, Laboratoire Technologies de l’Ingénierie Médicale et de la Complexité – Informatique, Mathématiques et Applications (TIMC-IMAG), F-38000, Grenoble, France;Centre National de Recherche Scientifique (CNRS), TIMC-IMAG, F-38000, Grenoble, France;Univ. Grenoble Alpes, Laboratoire Technologies de l’Ingénierie Médicale et de la Complexité – Informatique, Mathématiques et Applications (TIMC-IMAG), F-38000, Grenoble, France;Centre National de Recherche Scientifique (CNRS), TIMC-IMAG, F-38000, Grenoble, France;Conservatoire national des arts et métiers, Paris, France;Univ. Grenoble Alpes, Laboratoire Technologies de l’Ingénierie Médicale et de la Complexité – Informatique, Mathématiques et Applications (TIMC-IMAG), F-38000, Grenoble, France;Centre National de Recherche Scientifique (CNRS), TIMC-IMAG, F-38000, Grenoble, France;Ifremer, DYNECO/Pelagos, 29280, Plouzané, France;

关键词: Experimental evolution;    Escherichia coli;    Adaptation;    Historical contingency;    Epistasis;   

DOI  :  10.1186/s12862-016-0662-8

 received in 2016-01-05, accepted in 2016-04-19,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe impact of historical contingency, i.e. the past evolutionary history of a population, on further adaptation is mostly unknown at both the phenotypic and genomic levels. We addressed this question using a two-step evolution experiment. First, replicate populations of Escherichia coli were propagated in four different environmental conditions for 1000 generations. Then, all replicate populations were transferred and propagated for further 1000 generations to a single new environment.ResultsUsing this two-step experimental evolution strategy, we investigated, at both the phenotypic and genomic levels, whether and how adaptation in the initial historical environments impacted evolutionary trajectories in a new environment. We showed that both the growth rate and fitness of the evolved populations obtained after the second step of evolution were contingent upon past evolutionary history. In contrast however, the genes that were modified during the second step of evolution were independent from the previous history of the populations.ConclusionsOur work suggests that historical contingency affects phenotypic adaptation to a new environment. This was however not reflected at the genomic level implying complex relationships between environmental factors and the genotype-to-phenotype map.

【 授权许可】

CC BY   
© Plucain et al. 2016