Coffee and caffeine intake and male infertility: a systematic review

Nutrition Journal

Review

Edgardo Somigliana¹  Elena Ricci²  Sonia Cipriani²  Francesca Chiaffarino²  Fabio Parazzini³  Paola Viganò⁴  Alessandro Bulfoni⁵ 

[1] Department of Obstetrics, Gynecology and Neonatology, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy;Dipartimento della Donna, del Neonato e del Bambino, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Commenda 12, 20122, Milan, Italy;Dipartimento della Donna, del Neonato e del Bambino, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Commenda 12, 20122, Milan, Italy;Department of Clinical and Community Science, University of Milano, Milan, Italy;Reproductive Sciences Laboratory, Division of Genetics and Cell Biology, IRCCS Ospedale San Raffaele, Milan, Italy;Unit of Obstetrics and Gynaecology, Humanitas San Pio X Hospital, Milan, Italy;

关键词: Systematic review;    Male infertility;    Semen quality;    Sperm parameters;    Fecundability;    Coffee consumption;    Caffeine;    Life style;    Risk factors;   

DOI  :  10.1186/s12937-017-0257-2

 received in 2017-02-01, accepted in 2017-05-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSemen quality, a predictor of male fertility, has been suggested declining worldwide. Among other life style factors, male coffee/caffeine consumption was hypothesized to influence semen parameters, but also sperm DNA integrity. To summarize available evidence, we performed a systematic review of observational studies on the relation between coffee/caffeine intake and parameters of male fertility including sperm ploidy, sperm DNA integrity, semen quality and time to pregnancy.MethodsA systematic literature search was performed up to November 2016 (MEDLINE and EMBASE). We included all observational papers that reported the relation between male coffee/caffeine intake and reproductive outcomes: 1. semen parameters, 2. sperm DNA characteristics, 3. fecundability. All pertinent reports were retrieved and the relative reference lists were systematically searched in order to identify any potential additional studies that could be included.ResultsWe retrieved 28 papers reporting observational information on coffee/caffeine intake and reproductive outcomes. Overall, they included 19,967 men. 1. Semen parameters did not seem affected by caffeine intake, at least caffeine from coffee, tea and cocoa drinks, in most studies. Conversely, other contributions suggested a negative effect of cola-containing beverages and caffeine-containing soft drinks on semen volume, count and concentration. 2. As regards sperm DNA defects, caffeine intake seemed associated with aneuploidy and DNA breaks, but not with other markers of DNA damage. 3. Finally, male coffee drinking was associated to prolonged time to pregnancy in some, but not all, studies.ConclusionsThe literature suggests that caffeine intake, possibly through sperm DNA damage, may negatively affect male reproductive function. Evidence from epidemiological studies on semen parameters and fertility is however inconsistent and inconclusive. Well-designed studies with predefined criteria for semen analysis, subject selection, and life style habits definition, are essential to reach a consistent evidence on the effect of caffeine on semen parameters and male fertility.

【 授权许可】

CC BY   
© The Author(s). 2017