Therapeutic assessment of chloroquine–primaquine combined regimen in adult cohort of Plasmodium vivax malaria from a tertiary care hospital in southwestern India

Malaria Journal

Research

Asha Kamath¹  Manjunatha H Hande²  Kavitha Saravu²  Vasudeva Acharya²  Jayaprakash Belle²  Ananthakrishna B Shastry²  Sudha Vidyasagar²  Raviraja V Acharya²  Kumar Rishikesh² 

[1] Department of Community Medicine, Kasturba Medical College, Manipal University, Madhav Nagar, Manipal, India;Department of Medicine, Kasturba Medical College, Manipal University, Madhav Nagar, 576104, Manipal, Karnataka, India;

关键词: Malaria;    Plasmodium vivax;    Anti-malarials;    Treatment failure;    Chloroquine;    Primaquine;   

DOI  :  10.1186/s12936-015-0824-y

 received in 2015-05-19, accepted in 2015-07-28,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundOf late there have been accounts of therapeutic failure and chloroquine resistance in Plasmodium vivax malaria especially from Southeast Asian regions. The present study was conducted to assess the therapeutic efficacy of chloroquine–primaquine (CQ–PQ) combined regimen in a cohort of uncomplicated P. vivax mono-infection.MethodsA tertiary care hospital-based prospective study was conducted among adult cohort with mono-infection P. vivax malaria as per the World Health Organization’s protocol of in vivo assessment of anti-malarial therapeutic efficacy. Participants were treated with CQ 25 mg/kg body weight divided over 3 days and PQ 0.25 mg/kg body weight daily for 2 weeks.ResultsOf a total of 125 participants recruited, 122 (97.6%) completed day 28 follow up, three (2.4%) participants were lost to follow-up. Eight patients (6.4%) were ascertained to have mixed P. vivax and Plasmodium falciparum infection by nested polymerase chain reaction test. The majority of subjects (56.8%, 71/125) became aparasitaemic on day 2 followed by 35.2% (44/125) on day 3, and 8% (10/125) on day 7, and remained so thereafter. Overall only one therapeutic failure (0.8%, 1/125) occurred on day 3 due to persistence of fever and parasitaemia.ConclusionsCQ–PQ combined regimen remains outstandingly effective for uncomplicated P. vivax malaria and should be retained as treatment of choice in the study region. One case of treatment failure indicates possible resistance which warrants constant vigilance and periodic surveillance.

【 授权许可】

CC BY   
© Rishikesh et al. 2015