Antiretroviral Resistance in HIV/AIDS Patients

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Manosuthi, W.^1

Department of Medicine, Bamrasnaradura Infectious Diseases Institute, Ministry of Public Health, Tiwanon Road, Nonthaburi

11000, Thailand^1

关键词: Antiretroviral drugs;    Clinical decision;    Cross resistance;    Experienced people;    Mutation accumulations;    Pre-existing resistance;    Resistance testing;    Treatment failure;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012099/pdf
DOI  :  10.1088/1755-1315/125/1/012099

来源: IOP

【 摘 要 】

The higher prevalence of HIV drug resistance was observed in areas with greater ART coverage. The HIV resistance-associated mutations occur when people have inadequate levels of antiretroviral drugs as well as inadequate potency, inadequate adherence, and preexisting resistance. The degree to drug cross-resistance is observed depends on the specific mutations and number of mutation accumulation. In the Southeast Asia region, the challenging of people with treatment failure is the availability and accessibility to subsequent new antiretroviral drugs to construct he second and salvage regimen. Genotypic resistance testing is a useful tool because it can identify the existing drug resistance-associated mutations under the selective drug pressure. Thus, understanding the basic interpretation of HIV drug resistance- associated mutation is useful in guiding clinical decisions for treatment-experienced people living with HIV.