Cetirizine a histamine H1 receptor antagonist improves viral myocarditis

Journal of Inflammation

Research

Kanjo Yamamoto¹  Miho Shimada¹  Akira Matsumori¹ 

[1] Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine, Kyoto, Japan;

关键词: Mast Cell;    Cetirizine;    Tryptase;    Myocardial Necrosis;    Viral Myocarditis;   

DOI  :  10.1186/1476-9255-7-39

 received in 2009-05-29, accepted in 2010-08-04,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundWe showed that mast cells played a critical role in the progression of heart failure induced by pressure overload and viral myocarditis in mice. In this study, we investigated the effect of cetirizine, a selective H1 receptor antagonist, on experimental viral myocarditis induced by encephalomyocarditis (EMC) virus.MethodsFour-week-old inbred male DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units (pfu) of the EMC virus. Cetirizine was administered orally at a dose of 1 or 10 mg/kg per day for the survival study, and 1 mg/kg for the histologic and gene expression studies, beginning on the day of viral inoculation.ResultsCetirizine improved survival dose dependently. Heart weight to body weight ratio was significantly decreased in mice treated with cetirizine. The area of myocardial necrosis was significantly smaller in the hearts of mice treated with cetirizine compared with controls. Gene expressions of tumor necrosis factor, interleukin 6, and metalloproteinase 2 were significantly suppressed in the hearts of mice treated with cetirizine.ConclusionThese results suggest that cetirizine exerts its beneficial effects on viral myocarditis by suppressing expression of pro-inflammatory cytokines, genes related to cardiac remodeling in the hearts of mice.

【 授权许可】

CC BY   
© Matsumori et al; licensee BioMed Central Ltd. 2010