Moderate endurance training (marathon-training) – effects on immunologic and metabolic parameters in HIV-infected patients: the 42 KM cologne project

BMC Infectious Diseases

Research Article

Christoph Boesecke¹  Stefan Schlabe¹  Carolynne Schwarze-Zander¹  Jan-Christian Wasmuth¹  Martin Vogel¹  Jürgen K. Rockstroh¹  Christian Körner²  Klara Brixius³ 

[1] Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany;Department of Internal Medicine I, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany;Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany;Department of Molecular and Cellular Sport Medicine, Institute for Cardiovascular Research and Sport Medicine, German Sport University Cologne, Cologne, Germany;

关键词: Endurance training;    Marathon;    HIV-infection;   

DOI  :  10.1186/s12879-017-2651-y

 received in 2016-12-06, accepted in 2017-07-30,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundImproved treatment options of HIV have resulted in regular physical activities of many HIV-infected patients. However, data on effects of sports in HIV-patients are scarce.Methods21 HIV-infected persons were monitored prospectively while preparing for a marathon run. Multiple parameters with regard to immunology, quality of life and metabolism were measured at 4 time points (at baseline 1 year before the marathon run, 3 and 6 months after beginning of training, and immediately before marathon).Results13 out of 21 participants completed the marathon (12 male, 1 female; median age 42 years [27–50]; CD4 = 620/μl [146–1268]; 11 were on ART since 3.5 years [1–7]). 8 participants ceased training early. All reasons for stopping (besides one pre-existing metatarsal fracture) were not regarded as training-related (e.g. time limitation n = 3; newly diagnosed anal cancer n = 1; personal reasons/unknown n = 3).We observed a significant increase in absolute CD4-T-cells (620/μl [146–1268] vs. 745 [207–1647]; p = 0.001) with simultaneous decrease of CD4-T-cell apoptosis (53% [47–64] vs. 32% [14–42]); p < 0.01). No effects on viral load independent of ART occurred. Systolic blood pressure and cholesterol improved significantly, although moderate and normal at baseline (cholesterol 185 mg/dl [98–250] vs. 167 [106–222], p = 0.02; RRsys 125 mmHg [100–145] vs. 120 [100–140], p = 0.01). Blood count, liver enzymes, creatinine and CK remained unchanged.ConclusionsThe results of this pilot study indicated improved metabolic and immunologic parameters in HIV-infected patients undergoing moderate endurance training. Although training effects or ART cannot be ultimately separated as underlying mechanisms, we conclude that marathon training is safe for HIV-infected patients and potentially improves general health.Trial registrationDRKS00011592 (retrospectively registered on February 9th 2017).

【 授权许可】

CC BY   
© The Author(s). 2017