Seroepidemiology of human enterovirus71 and coxsackievirusA16 among children in Guangdong province, China

BMC Infectious Diseases

Research Article

Lina Yi¹  Jing Lu¹  Juan Su²  Yonghui Zhang²  Hanri Zeng²  Cong Ma²  Dawei Guan²  Jinyan Lin²  Changwen Ke²  Wanly Zhang²  Hong xiao²  Wei Li²  Hui Li² 

[1] Department of Pathogen Detection Research for Emerging Infectious Diseases, Center for Disease Control and Prevention of Guangdong Province, Guangzhou, China;Guangdong Provincial Institution of Public Health, Guangzhou, Guangdong, China;Department of Pathogen Detection Research for Emerging Infectious Diseases, Center for Disease Control and Prevention of Guangdong Province, Guangzhou, China;Key Laboratories of Pathogen Detection for Emergency Response, Center for Disease Control and Prevention of Guangdong Province, Guangzhou, Guangdong, China;Key Laboratories of Depository and Application for Pathogenic Microbiology, Center for Disease Control and Prevention of Guangdong Province, Guangzhou, Guangdong, China;

关键词: Enterovirus 71;    Coxsackievirus A 16;    Seroprevalence;   

DOI  :  10.1186/1471-2334-13-322

 received in 2013-03-17, accepted in 2013-07-10,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundHand, foot and mouth disease (HFMD) is a common pediatric illness. Mainly induced by the Enterovirus 71 and Coxsackievirus A 16 infections, the frequently occurred HFMD outbreaks have become a serious public health problem in Southeast Asia. Currently,only a few studies have investigated the human immunity to HFMD in China. In this study, we conducted a cohort study in Guangdong province, China.MethodsStored serum samples from children less than 10 years old were analyzed. The levels of EV71 and CA16 specific antibodies before, during and shortly after the 2008 large outbreak of HFMD were evaluated by the microneutralization test. The geometric mean titer (GMT) was calculated and compared. Statistical significance was taken as P < 0.05.ResultsThe seroprevalence data showed a continuous circulation of EV71 and CA16 in Guangdong province China in 2007–2009. The low positive rate in 2009 correlated well with the unprecedented outbreak of HFMD in 2010. Age related increase of seroprevalence was identified in 1–3 years old children for EV71 and in 1–5 years old children for CA16 in Guangdong province. High GMT of EV71 and CA16 antibody titers were also found for these age groups.ConclusionsAll of the above findings indicated common infections for these age groups. And they should clearly be at the top of the priority in periodical seroprevalence survey and future vaccination campaign.

【 授权许可】

Unknown   
© Li et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.