EVALUATION OF THE PROTECTIVE EFFICACY OF HIV-1 PROTEASE INHIBITORS AGAINST ENTEROVIRUS 71 INFECTION IN VITRO

Enterovirus 71;Hand foot and mouth disease;HIV-1 protease inhibitors;antiviral;drug;in vitro;not listed

Kurapati, SravyaYu, Xiao-Fang ;

Johns Hopkins University

关键词: Enterovirus 71;    Hand foot and mouth disease;    HIV-1 protease inhibitors;    antiviral;    drug;    in vitro;    not listed;   

Others  :  https://jscholarship.library.jhu.edu/bitstream/handle/1774.2/37284/KURAPATI-THESIS-2014.pdf?sequence=1&isAllowed=y

瑞士|英语

来源: JOHNS HOPKINS DSpace Repository

【 摘 要 】

Enterovirus associated hand, foot and mouth disease continues to be a prominent public health issue despite the numerous vaccine trials and drug development attempts. The lack of a specific and protective antiviral drug has made disease management extremely challenging and gravely underscores the need for effective therapy options. Nelfinavir, belonging to the HIV-1 protease inhibitors, was found to have significant antiviral activity compared to other HIV-1 protease inhibitors. With a low cytotoxicity and high inhibitory action against both the BrCr and H strain of EV71, nelfinavir exhibited potential broad spectrum antiviral properties. Additionally, its ability to impede the virus irrespective of the stage of the infection makes it a more promising therapeutic option. The data strongly support the potential usefulness of nelfinavir as a broad spectrum antiviral drug with significant protective efficacy against EV71 infection in vitro.