The Epidemiology of Staphylococcus aureus and Panton-Valentine Leucocidin (pvl) in Central Australia, 2006-2010

BMC Infectious Diseases

Research Article

S. Hewagama¹  L. Einsiedel²  J. McLeod³  T. Spelman⁴  D. Gordon⁵  M. Woolley⁵ 

[1] Alice Springs Hospital, Alice Springs, NT, Australia;Alice Springs Hospital, Alice Springs, NT, Australia;Flinders University/Northern Territory Rural Clinical School, Alice Springs, NT, Australia;Baker IDI Heart and Diabetes Institute, Alice Springs, NT, Australia;Alice Springs Hospital, Alice Springs, NT, Australia;NT Pathology, Alice Springs, NT, Australia;Flinders University/Northern Territory Rural Clinical School, Alice Springs, NT, Australia;SA Pathology, Adelaide, Australia;

关键词: Staphylococcus aureus;    Panton-Valentine Leucocidin;    ST93;   

DOI  :  10.1186/s12879-016-1698-5

 received in 2016-03-17, accepted in 2016-07-08,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe Central Australian Indigenous population has a high incidence of Staphylococcus aureus bacteremia (SAB) but little is known about the local molecular epidemiology.MethodsProspective observational study of bacteremic and nasal colonizing S.aureus isolates between June 2006 to June 2010. All isolates underwent single nucleotide polymorphism (SNP) genotyping and testing for the presence of the Panton-Valentine Leucocidin (pvl) gene.ResultsInvasive isolates (n = 97) were predominantly ST93 (26.6 %) and pvl positive (54.3 %), which was associated with skin and soft tissue infections (OR 4.35, 95 % CI 1.16, 16.31). Non-multiresistant MRSA accounted for 31.9 % of bacteremic samples and showed a trend to being healthcare associated (OR 2.16, 95 % CI 0.86, 5.40). Non-invasive isolates (n = 54) were rarely ST93 (1.9 %) or pvl positive (7.4 %).ConclusionsIn Central Australia, ST93 was the dominant S.aureus clone, and was frequently pvl positive and associated with an aggressive clinical phenotype. Whether non-nasal carriage is more important with invasive clones or whether colonization occurs only transiently remains to be elucidated.

【 授权许可】

CC BY   
© The Author(s). 2016