Microvascular ischemia in hypertrophic cardiomyopathy: new insights from high-resolution combined quantification of perfusion and late gadolinium enhancement

Journal of Cardiovascular Magnetic Resonance

Research

Gerald Carr-White¹  Eike Nagel²  Adriana D. M. Villa³  Niloufar Zarinabad³  Eva Sammut³  Jack Lee³  Reza Razavi³  Amedeo Chiribiri⁴  Nuno Bettencourt⁵ 

[1] Cardiology Department, St Thomas’ Hospital, London, UK;DZHK Centre for Cardiovascular Imaging, University Hospital Frankfurt / Main, Frankfurt am Main, Germany;Division of Imaging Sciences, King’s College London, Wellcome Trust/EPSRC Medical Engineering Centre, St Thomas’ Hospital, London, UK;Division of Imaging Sciences, King’s College London, Wellcome Trust/EPSRC Medical Engineering Centre, St Thomas’ Hospital, London, UK;Division of Imaging Sciences and Biomedical Engineering, King’s College London, The Rayne Institute – 4th Floor Lambeth Wing, St Thomas’ Hospital, SE1 7EH, London, UK;Hospital Center Vila Nova Gaia, Porto, Portugal;

关键词: Hypertrophic cardiomyopathy;    Stress test;    Perfusion imaging;    Adenosine;    Late gadolinium enhancement;    Cardiovascular magnetic resonance;   

DOI  :  10.1186/s12968-016-0223-8

 received in 2015-10-10, accepted in 2016-01-05,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMicrovascular ischemia is one of the hallmarks of hypertrophic cardiomyopathy (HCM) and has been associated with poor outcome. However, myocardial fibrosis, seen on cardiovascular magnetic resonance (CMR) as late gadolinium enhancement (LGE), can be responsible for rest perfusion defects in up to 30 % of patients with HCM, potentially leading to an overestimation of the ischemic burden. We investigated the effect of left ventricle (LV) scar on the total LV ischemic burden using novel high-resolution perfusion analysis techniques in conjunction with LGE quantification.Methods30 patients with HCM and unobstructed epicardial coronary arteries underwent CMR with Fermi constrained quantitative perfusion analysis on segmental and high-resolution data. The latter were corrected for the presence of fibrosis on a pixel-by-pixel basis.ResultsHigh-resolution quantification proved more sensitive for the detection of microvascular ischemia in comparison to segmental analysis. Areas of LGE were associated with significant reduction of myocardial perfusion reserve (MPR) leading to an overestimation of the total ischemic burden on non-corrected perfusion maps. Using a threshold MPR of 1.5, the presence of LGE caused an overestimation of the ischemic burden of 28 %. The ischemic burden was more severe in patients with fibrosis, also after correction of the perfusion maps, in keeping with more severe disease in this subgroup.ConclusionsLGE is an important confounder in the assessment of the ischemic burden in patients with HCM. High-resolution quantitative analysis with LGE correction enables the independent evaluation of microvascular ischemia and fibrosis and should be used when evaluating patients with HCM.

【 授权许可】

CC BY   
© Villa et al. 2016