Value of soluble Urokinase plasminogen activator receptor over age as a biomarker of impaired myocardial relaxation

BMC Geriatrics

Research Article

Jian-Min Yuan¹  Woon-Puay Koh²  Bhaarathy Velmurugan³  Christine Cheung⁴  Serene J. M. Chua⁵  Louis L. Y. Teo⁵  Jia-Ing Wong⁵  Bryan M. H. Keng⁵  Ru San Tan⁶  Fei Gao⁶  Angela S. Koh⁶ 

[1] Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA;Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA;Duke-NUS Medical School, Singapore, Singapore;Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore;Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore;Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore;Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore;National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore, Singapore;National Heart Centre Singapore, 5 Hospital Drive, 169609, Singapore, Singapore;Duke-NUS Medical School, Singapore, Singapore;

关键词: Soluble urokinase plasminogen activator receptor;    Biomarker;    Cardiac function;    Cardiovascular disease;    Elderly;    Ageing;   

DOI  :  10.1186/s12877-017-0668-0

 received in 2017-08-23, accepted in 2017-11-15,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundSuPAR is a biomarker that reflects the level of immune activation. As inflammation plays an important role in the ageing process of the cardiovascular system, we hypothesized that suPAR might be a useful predictive biomarker of the ageing heart.MethodsWe performed conventional and tissue Doppler echocardiography and measured plasma suPAR levels.ResultsWe studied community adults (n=120, 37.5% female) (mean age: 70.3±9.3 years) without known cardiovascular disease (CVD). Participants with impaired myocardial relaxation were older (84% vs 59% were aged ≥71 years, p=0.002), with more diabetes mellitus (27% vs 11%, p=0.034). SuPAR levels were higher among participants with impaired myocardial relaxation (3.9 ng/ml vs 3.0 ng/ml, p=0.015). At the univariate level, older age (OR 3.6; 95%CI 1.6, 8.5; p=0.003), diabetes mellitus (OR 3.04; 95%CI 1.1, 8.8; p=0.04), systolic blood pressure (OR 1.03; 95%CI 1.001, 1.1; p=0.041) and suPAR levels ≥3.00ng/ml (OR 3.4; 95%CI 1.16, 7.4; p=0.002) were associated with impaired myocardial relaxation. In multivariable regression analysis, only older age (OR 2.8; 95%CI 1.1, 6.7; p=0.026) and suPAR (OR 2.7; 95%CI 1.2, 6.1; p=0.018) remained independently associated with impaired myocardial relaxation. Receiver operating characteristics (ROC) curve analysis revealed an area under the curve (AUC) value of 0.63 (95% CI 0.54, 0.71) for model that included age alone. Addition of suPAR significantly increased AUC value to 0.70 (95%CI 0.60, 0.79), which was significantly larger than the model with age alone (p=0.016).ConclusionWe demonstrate additional ability of suPAR, over age, to predict impaired myocardial relaxation.Trial registrationClinicalTrials.gov Identifier: NCT02791139 (Registered May 31, 2016).

【 授权许可】

CC BY   
© The Author(s). 2017