The associations between endothelial lipase 584C/T polymorphism and HDL-C level and coronary heart disease susceptibility: a meta-analysis

Lipids in Health and Disease

Research

Weijin Weng¹  Ganwei Shi¹  Gaojun Cai¹  Bifeng Zhang²  Zhiying Huang³ 

[1] Department of Cardiology, Wujin Hospital Affiliated to Jiangsu University, Changzhou, Jiangsu Province, China;Department of Medicine, University of Chicago, Chicago, Illinois, USA;Department of Pediatrics, NO.2 Hospital of Changzhou, Changzhou, Jiangsu, China;

关键词: Endothelial lipase;    High density lipoprotein cholesterol;    Polymorphism;    Coronary heart disease;    Meta-analysis;   

DOI  :  10.1186/1476-511X-13-85

 received in 2014-03-15, accepted in 2014-05-04,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundStudies had investigated the relationships between endothelial lipase (EL) 584C/T polymorphism and high density lipoprotein cholesterol (HDL-C) level and coronary heart disease (CHD), but the results were controversial. To investigate a more authentic associations between EL 584C/T polymorphism and HDL-C level, and the risk of CHD, we performed this meta-analysis.MethodsWe searched electric databases for all articles on the associations between EL 584C/T polymorphism and HDL-C level, and CHD risk. Odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the strength of the association between the EL 584C/T polymorphism and the CHD susceptibility. The pooled standardized mean difference (SMD) with 95% CI was used for the meta-analysis of EL 584C/T polymorphism and HDL-C level. Begg’s funnel plots and Egger’s test were used to examine the publication bias.ResultsFor CHD association, the pooled OR was 0.829 (95% CI: 0.701-0.980, P = 0.028) for the dominant model and 0.882 (95% CI: 0.779-0.999, P = 0.049) for the allelic model. By meta-regression analysis, we found that only total sample size could influence the initial heterogeneity. When the subgroup analysis was carried out, we found that the protective effect only existed in the subgroups of relatively small sample size. Sensitivity analyses indicated that Tang’s study influenced the overall results significantly. We calculated the pooled ORs again after excluding Tang’s study and found the association between EL 584C/T polymorphism and the risk of CHD was not significant for any genetic model. For HDL-C level association, the carriers of 584 T allele had a higher HDL-C level than the non-carriers. The pooled SMD was 0.399 (95% CI: 0.094-0.704, P = 0.010). When the studies were stratified by ethnicity and total sample size, the positive effects existed in the Caucasians and in subgroups of larger sample size. No significant publication bias was found in the present meta-analysis.ConclusionsThe results of the present meta-analysis suggest that the carriers of EL 584 T allele have a higher HDL-C level in Caucasian populations. Whereas, it might not be a protective factor for CHD.

【 授权许可】

CC BY   
© Cai et al.; licensee BioMed Central Ltd. 2014